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Genetic polymorphisms and intrauterine development. Evidence of decreased heterozygosity in light-for-dates human newborn babies

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Summary

In 2 independent samples of low-birth-weight infants the proportion of females and homozygotes for a series of polymorphic systems was higher in light-for-dates than in preterm babies. The observation seems to give support to the hypothesis that homozygosity for ‘normal’ polymorphisms may decrease in general intrauterine growth rate. Since it is known that survival rate is strongly related to birth weight, a correlation between growth retardation and homozygosity may have a major role in the maintenance of such polimorphisms.

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Authors and Affiliations

  1. Dept. of Genetics and Computer Center, University of Camerino, I-62032, Camerino, Italy

    E. Bottini, F. Gloria-Bottini, P. Lucarelli, A. Polzonetti, F. Santoro & A. Varveri

  2. Center of Evolutionary Genetics of CNR and ‘Bambino Gesù’ Hospital for Sick Children, Rome, Italy

    E. Bottini, F. Gloria-Bottini, P. Lucarelli, A. Polzonetti, F. Santoro & A. Varveri

Authors
  1. E. Bottini
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  2. F. Gloria-Bottini
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  3. P. Lucarelli
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  4. A. Polzonetti
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  5. F. Santoro
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  6. A. Varveri
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Additional information

We thank Prof. L. Ginzburg for helpful comments.

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Bottini, E., Gloria-Bottini, F., Lucarelli, P. et al. Genetic polymorphisms and intrauterine development. Evidence of decreased heterozygosity in light-for-dates human newborn babies. Experientia 35, 1565–1567 (1979). https://doi.org/10.1007/BF01953195

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  • DOI: https://doi.org/10.1007/BF01953195

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