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Centrally acting hypotensive fraction in the venom ofDendroaspis angusticeps

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Summary

I.v. administration of 100 μg/kg ofDendroaspis angusticeps venom produced a biphasic vasodepressor response. The first fall in blood pressure is due to a cholinergic component, whereas the second fall may be due to central depressant effect.

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Literatur

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Author information

Author notes

  1. K. Thairu

    Present address: Department of Physiology, University of Nairobi, Nairobi, Kenya

Authors and Affiliations

  1. Division of Pharmacology and Therapeutics, P.O. Box 30588, Nairobi, (Kenya)

    J. Wangai, J. N. Ng'ang'a, D. Njoroge, K. Thairu & B. V. Telang

Authors
  1. J. Wangai
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  2. J. N. Ng'ang'a
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  3. D. Njoroge
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  4. K. Thairu
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  5. B. V. Telang
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Additional information

The work reported here was undertaken in partial fulfilment of the requirements for the degree of PhD of the University of Nairobi.

Acknowledgment. We are grateful to the University of Nairobi for the research grant (No. 670-052) which supported this work. We also thank Merck, Sharp & Dohme Ltd for a liberal supply of cyproheptadine and Mr E. Njogu (chief technician, Dept of Veterinary Anatomy) for photographic assistance.

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Wangai, J., Ng'ang'a, J.N., Njoroge, D. et al. Centrally acting hypotensive fraction in the venom ofDendroaspis angusticeps . Experientia 34, 874–876 (1978). https://doi.org/10.1007/BF01939676

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  • DOI: https://doi.org/10.1007/BF01939676

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