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Der Einfluß des extrazellulären Calciums auf die Saft-, Enzym- und Calciumsekretion des isoliert perfundierten Hundepankreas

The influence of extracellular Calcium on volume, enzyme and Calcium secretion in the isolated perfused canine pancreas

  • Published:
Research in Experimental Medicine

Summary

  1. 1.

    The kinetics of Ca++ and enzyme secretion are of corresponding pattern as well at hydrokinetic as at ecbolic stimulation.

  2. 2.

    Physiological respectively pathophysiologically relevant changes of perfusate Ca++ concentrations do not influence pancreatic Ca++ secretion. Extracellular Ca++ concentrations beyond 12 mEq/1 initiate an enzyme independent Ca++ secretion.

  3. 3.

    Hydrokinetic or ecbolic stimulated panereatic secretion do not distinguish in calcium/protein ratio.

  4. 4.

    Basal and stimulated enzyme secretion of isolated perfused canine pancreas remain unaffected by increments of extracellular Ca++ concentrations even at pharmacological values.

  5. 5.

    The stimulated enzyme- and Ca++ secretion remain constant during hypocalcemic perfusate conditions but decrease to basal values in Ca++ free media, rapidly and completely reversible by recalcification of the perfusate.

  6. 6.

    The secretin stimulated volume secretion remains unchanged either by extremely hypercalcemic or Ca++ depleted perfusate conditions.

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Authors and Affiliations

  1. II. Medizinische Klinik, Universität München, Ziemssenstraße 1, D-8000, München 2, Germany

    H. Teufel, P. Stock, H. Rohrmoser & M. M. Forell

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  1. H. Teufel
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  2. P. Stock
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  3. H. Rohrmoser
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  4. M. M. Forell
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Durchgeführt mit Unterstützung der Deutschen Forschungsgemeinschaft

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Teufel, H., Stock, P., Rohrmoser, H. et al. Der Einfluß des extrazellulären Calciums auf die Saft-, Enzym- und Calciumsekretion des isoliert perfundierten Hundepankreas. Res. Exp. Med. 169, 221–241 (1977). https://doi.org/10.1007/BF01852061

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  • DOI: https://doi.org/10.1007/BF01852061

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