Summary
The influence of a preparation (Esberitox) which is claimed to be a non-specific stimulator of host resistance was examined in macrophages attaching to s.c. implanted coverslips in rats. Not only did this preparation significantly increase macrophage numbers but it also very significantly increased the proportion which were stimulated.
Similar content being viewed by others
References
Alexander JW, Dionig RD, Meakins JL (1971) Periodic variation in the bacterial function of human neutrophils and its relationship to sepsis. Ann Surg 173:206–213
Beuscher N, Beuscher H, Otto B, Schäfer B (1977) Über die medikamentöse Beeinflussung zellulärer und humoraler Resistenzmechanismen im Tierversuch. I. In vitro-Untersuchungen an Peritoneal-Leukozyten und Seren der Ratte. Arzneim Forsch (Drug Res) 27:1655–1660
Beuscher N, Beuscher H, Schäfer B (1978) Über die medikamentöse Beeinflussung zellulärer Resistenzmechanismen im Tierversuch. Mitt. Untersuchungen an Granulozyten aus entzündlichen Peritoneal-Exsudaten der Ratte. Arzneim Forsch (Drug Res) 28:2242–2246
Davies P, Bonney RJ (1979) Secretory products of mononuclear phagocytes. A brief review. J Reticuloendothel Soc 26:37–45
Gerhardt P (1972) Über den Einfluß einer unspezifischen Reiztherapie mit Esberitox auf die Leukopoese bei der Anwendung tonisierender Strahlen. Strahlenther 143:549–558
Hopper KE, Wood PR, Nelson DS (1979) Macrophage heterogeneity. Vox Sang 36:251
Kirchberg H (1958) Beeinflussung der Strahlenleukopenie durch Esberitox. Ringelh Biol Umsch 7/8:49–57
Lamperle G, Reichelt M (1973) Der Lipofundin-Clearance-Test. Med Klin 68:48–56
Leidberg CF (1961) Antibacterial resistance in burns. II. The effect on unspecific humoral defense mechanisms, phagocytosis and the development of bacteremia. An experimental study in the guinea pig. Acta Chir Scand 121:351–358
Mauer H, Foh P (1953) Untersuchungen über den Einfluß von tuberkulösen Toxinen, Chemotherapeutica und Antibiotica auf die leukozytäre Farbstoffphagozytose in vitro. Beitr Klin Tuberk 109:471–477
Morland B, Kaplan G (1977) Macrophage activation in vivo and in vitro. Exp Cell Res 108:279–288
Piller NB (1978) A morphological assessment of the stimulatory effect of coumarin on macrophages. Br J Exp Pathol 59:93–96
Piller NB (1980) Lymphoedema, macrophages and benzopyrones. Lymphology 13:109–119
Piller NB, Clodius L (1979) A morphological assessment of macrophages attaching to subcutaneously implanted coverslips in dogs with chronic lymphoedema. Br J Exp Pathol 60:328–334
Piller NB, Clodius L (1980) The role of the mononuclear phagocytic system in lymphoedema and its relationship with histopathological changes in the functioning of the blood-tissue lymph system. Z Lymphol 4:35–42
Pohl P (1970) Zur Therapie der strahlenbedingten Leukopenie mit Esberitox. Ther Ggw 109:902–906
Quadripur SA (1974) Untersuchungen über Phagozytose. Z Ther 12:281–284
Quadripur SA (1976) Medikamentöse Beeinflussung der Phagozytosefähigkeit der Granulozyten. Ther Ggw 115:1072–1078
Rittenbury MS, Hanback LD (1967) Phagocytic depression in thermal injuries. J Traumatol 7:523–540
Sartor KJ (1972) Zur Wirksamkeit von Esberitox in der Behandlung strahlenbedingter Leukopenien. Ther Ggw 111:1147–1150
Schmeling A, Quie PG (1974) Effect of tetracycline in the phagocytic function of human leucocytes. J Infect Dis 130:412–415
Volkman A, Gowans IL (1965) The production of macrophages in the rat. Br J Exp Pathol 46:50–56
Warner GF, Dobson EL (1954) Disturbances in the reticuloendothelial system following thermal injury. Am J Physiol 179:93–98
Zweifach BW, Benacerraf B, Thomas L (1957) The relationship between the vascular manifestations of shock produced by endotoxins, trauma and hemorrhage. II. The possible role of the RES in resistance to each type of shock. J Exp Med 106:403–414
Author information
Authors and Affiliations
Additional information
Manufacturer: Schaper and Brümmer, Salzgitter-Ringelheim, FRG. Each 20ml contains: Percolat. 1=5: Herb. Thujae 1 ml; Rad. Baptisiae 2 ml Percolat. 1 = 10: Echinaceae 3 ml; Apis mell. D 4.2 ml: Crotalus D 6.3 ml; Silicea D 4.3 ml; Lachesis D 6.6 ml
Rights and permissions
About this article
Cite this article
Piller, N.B. The influence of a non-specific stimulator of host resistance on the number and morphological characteristics of macrophages attaching to subcutaneously implanted coverslips in the rat. Res. Exp. Med. 179, 255–259 (1981). https://doi.org/10.1007/BF01851623
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01851623