Skip to main content
Log in

Nimodipine: a new calcium antagonistic drug with a preferential cerebrovascular action

  • Published:
Acta Neurochirurgica Aims and scope Submit manuscript

Summary

Nimodipine, isopropyl (2-methoxy-ethyl) l,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate, is a new calcium antagonistic vasodilator with a preferential effect on brain vessels.

Nimodipine prevents spasm of the isolated rabbit basilar artery produced both by depolarization and by receptor stimulation. In peripheral vessels nimodipine does not inhibit agonistically induced contractions.

In vivo nimodipine also dilates predominantly cerebral vessels ; peripheral vasodilation resulting in a decrease in blood pressure is much less pronounced. Nimodipine prevents the impaired reperfusion of the brain caused by a transitory global cerebral ischaemia.

Nimodipine is predicted to be useful in the prophylaxis and treatment of cerebral vasospasm in humans.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Allen, G. S., Bahr. A. L., Cerebral arterial spasm: Part 10. Reversal of acute and chronic spasm in dogs with orally administered nifedipine. Neuro- surgery4 (1979), 43–46.

    Google Scholar 

  2. Kazda, S., Hoffmeister, F., Effect of some cerebral vasodilators on the postischaemic impaired cerebral reperfusion in cats. Arch. Pharmacol. Suppl.307 (1979), R43.

    Google Scholar 

  3. Kazda, F., Hoffmeister, F., Garthoff, B., Towart, R., Prevention of the postischaemic impaired reperfusion of the brain by nimodipine (BAY e 9736). Acta Neurol. Scand.60, Suppl.72 (1979), 302–303.

    Google Scholar 

  4. Kazda, S., Towart, R., Differences in the effect of the calcium antagonists nimodipine (BAY e 9736) and bencyclan on cerebral and peripheral vascular smooth muscle. Brit. J. Pharmacol.72 (1980), 582P-583P.

    Google Scholar 

  5. Towart, R., The selective inhibition of serotonin-induced contractions of rabbit cerebral vascular smooth muscle by calcium antagonistic dihydro- pyridines: an investigation of the mechanism of action of nimodipine. Circ. Res.48 (1981), 650–657.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kazda, S., Towart, R. Nimodipine: a new calcium antagonistic drug with a preferential cerebrovascular action. Acta neurochir 63, 259–265 (1982). https://doi.org/10.1007/BF01728880

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01728880

Keywords

Navigation