Summary
Immunohistochemical examinations of 89 breast cancer specimens were performed using two different monoclonal antibodies. One marked the nuclear estrogen-receptor (ER) protein (anti-ER, Abbott), whereas the other marked an ER-related cytoplasmic protein (ER-D5 Amersham). Comparison of the results of the biochemical assay with those of the immunohistochemical markers revealed the following correlations: 75% anti ER and 71% ER-D5. Clinical follow-up studies are necessary to specify the relevance of these new immunohistochemical techniques in the anti-hormonal therapeutic management of breast cancer patients.
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Abbreviations
- Ak:
-
Antikörper
- APAAP:
-
Alkalische Phosphatase, anti-alkalische Phosphatase
- DAB:
-
Diaminobenzidin
- DCC:
-
Dextran-coated-charcoal
- E:
-
Östrogen
- ER:
-
Östrogenrezeptor
- PAP:
-
Peroxidase anti-Peroxidase
- PR:
-
Progesteronrezeptor
- S:
-
Sensitivität
- Ü:
-
Übereinstimmung
- Z:
-
Spezifität
Literatur
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Brehler, R., Bergholz, M., Rauschecker, H. et al. Immunhistochemische Untersuchungen zur Bestimmung des Hormonrezeptorstatus von Mammakarzinomen. Klin Wochenschr 64, 370–374 (1986). https://doi.org/10.1007/BF01728186
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DOI: https://doi.org/10.1007/BF01728186