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Granulocytic sarcoma of the prostate as the first manifestation of a late relapse of acute myelogenous leukemia

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Summary

We describe a 68-year-old patient who developed granulocytic sarcoma of the prostate 9 years after complete remission following successful treatment of acute myelogenous leukemia (FAB, M2). PCR analysis of bone marrow samples in first remission and at the time of relapse detected an AML1/ETO rearrangement typical for AMLs with t (8; 21). The CD 56 antigen was not expressed on the leukemic cells. Systemic chemotherapy led to a short-lasting regression of the tumor, but the patient subsequently developed overt bone marrow relapse and died during chemotherapy. While granulocytic sarcoma as a primary manifestation of AML is well known, as the first manifestation of relapse it appears to be very uncommon.

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Authors and Affiliations

  1. Klinik für Innere Medizin I, Abteilung für Hämatologie, Währinger Gürtel 18-20, A-1090, Vienna, Austria

    F. Thalhammer, H. Gisslinger, R. Kusec, W. Linkesch, K. Lechner & U. Jäger

  2. Department of Clinical Pathology, University of Vienna, Austria

    A. Chott & I. Simonitsch

  3. Department of Pediatrics, St. Anna Children's Hospital, Vienna, Austria

    O. Haas

  4. Department of Urology, University of Vienna, Austria

    A. Etele-Hainz

  5. Department of Radiology, University of Vienna, Austria

    T. Helbich

  6. Institute of Immunology, University of Vienna, Austria

    H. Strobl

Authors
  1. F. Thalhammer
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  2. H. Gisslinger
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  3. A. Chott
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  4. O. Haas
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  5. A. Etele-Hainz
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  6. T. Helbich
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  7. R. Kusec
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  8. W. Linkesch
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  9. I. Simonitsch
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  10. H. Strobl
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  11. K. Lechner
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  12. U. Jäger
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Thalhammer, F., Gisslinger, H., Chott, A. et al. Granulocytic sarcoma of the prostate as the first manifestation of a late relapse of acute myelogenous leukemia. Ann Hematol 68, 97–99 (1994). https://doi.org/10.1007/BF01715141

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  • DOI: https://doi.org/10.1007/BF01715141

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