Summary
Previously unreported metabolites from the urine of rats fed lindane have been identified as 3,4-dichlorophenol, 2,4,6-trichlorophenol, 2,3,4,5-tetrachlorophenol, 2,3,4,6-tetrachlorophenol and 2,3,4,5,6-pentachloro-2-cyclohexen-1-ol. While the 3,4-dichlorophenol is a minor metabolite, the others are excreted in greater quantities than either 2,3,5- or 2,4,5-trichlorophenol, previously identified lindane metabolites. The excretion of tetrachlorophenols and PCCOL require a revision in the currently accepted theory regarding the metabolism of lindane by mammals.
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Chadwick, R.W., Freal, J.J. The identification of five unreported lindane metabolites recovered from rat urine. Bull. Environ. Contam. Toxicol. 7, 137–146 (1972). https://doi.org/10.1007/BF01684805
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DOI: https://doi.org/10.1007/BF01684805