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“No-effect-level” of melathion (0,0′-dimethyl dithiophosphate of diethyl mercaptosuccinate) inBubalus bubalis

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Summary

An oral dose of 0.5 mg/kg/day malathion continuously administered for one year has been investigated to produce no change in biochemical (RChE, PChE, aspartate-and alanine aminotransferases, blood glucose, serum urea and plasma total proteins) or haematological (Hb, PCV, tRBC and tWBC) parameters and, therefore, considered to be “no-effect-level” inBubalus bubalis. However, the administration of higher doses (1.0 and 1.5 mg/kg/day) produced significant (P<0.05) changes in all biochemical parameters studied. With these doses leucocytosis was evident among haematological parameters measured.

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References

  • BRENT, E., and BERGMYER, H.U.: Methods of Enzymatic Analysis. New York, Academic Press. 1965.

    Google Scholar 

  • DENMANN, B., HAMDI, E., FOX, C., and FRAZOLA, W: Arch. Environ. Hlth.7, 640 (1963).

    Google Scholar 

  • FAO/WHO.: Evaluation of the toxicity of pesticides residues in Food, FAO Meeting. Rep. No. PL/1965/10; WHO/Food Add/26. 1965.

  • FLOREY, L.: General Pathology. 4th ed. London. Lloyd Luke Ltd. 1970.

    Google Scholar 

  • FRANKEL, S., REITMAN, S., and SONNERWIRTHA, A.C.: Gradwohl's Clinical Laboratory Methods and Diagnosis Vol. I. St. Louis. The C.V. Mosby Co. 1970.

    Google Scholar 

  • GUPTA, R.C., and PAUL, B.S: Pesticides.11(8), 26(1977).

    Google Scholar 

  • KACEW, S., SINGHAL, R.L., HRDINA, P.D. and LING, G.M.: J. Pharmacol. Exp. Therap.181. 234 (1972).

    Google Scholar 

  • LI, J.C.R.: Statistical Inference. Vol. I. Michigan, Eduard Brothers Inc. 1964.

    Google Scholar 

  • MICHEL, H.O.: J. Lab. Clin. Pled.34, 1564 (1949).

    Google Scholar 

  • REITMAN, S., and FRANKEL, S.: Am. J. Clin. Path.28, 26. (1957).

    Google Scholar 

  • ROUILLER, CH.: The liver morphology, biochemistry and physiology, New York, Academic Press. 1964.

    Google Scholar 

  • SONI, B.K., KUMARAN, J.D.S., and SINGH, S.P. Laboratory Manual of Experimental Physiology. Pantnagar, University Press. 1967.

    Google Scholar 

  • VADLAMUDI, V.P.: Biochemico-Toxicological studies on organophosphorus insecticides (malathion and sumithion) in buffalo calves. Ph.D. Thesis. PAU, Ludhiana. 1974.

    Google Scholar 

  • WEISS, L.R., BRYANT, J., and FITZHUGH, O.G. Toxicol. Appl. Pharmacol.6, 363 (1964).

    Google Scholar 

  • WOOTTON, I.D.P.: Microanalysis in Medical Biochemistry. London, J. and A. Churchill Ltd. 1964.

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, Punjab Agricultural University, 141 004, Ludhiana, India

    R. C. Gupta & B. S. Paul

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  1. R. C. Gupta
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  2. B. S. Paul
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Gupta, R.C., Paul, B.S. “No-effect-level” of melathion (0,0′-dimethyl dithiophosphate of diethyl mercaptosuccinate) inBubalus bubalis . Bull. Environ. Contam. Toxicol. 20, 819–825 (1978). https://doi.org/10.1007/BF01683606

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