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D-19466, a new cyclobutane-platinum complex with antitumor activity

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  • Experimental Oncology
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Summary

D-19466, a new platinum complex, was characterized. It showed no nephrotoxic side-effects as determined by the measurement of blood urea. It was cytotoxic in vitro for tumor cells in concentrations comparable to or lower than cytotoxic concentrations of cisplatin. It had excellent anticancer activity in vivo against a number of murine experimental tumors, including a cisplatin-resistant P388 line. Clinical evaluation of this compound has therefore been initiated.

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References

  • Canetta R, Bragman K, Smaldone L, Rozencweig M (1988) Carboplatin: current status and future prospects. Cancer Treat Rev 15:17–32

    Google Scholar 

  • DeVita VT, Hellmann S, Rosenberg SA (eds) (1989) Cancer, principles and practice of oncology. Lippincott, Philadelphia, p 373–375

    Google Scholar 

  • Hamburger AW, Salmon SE (1977) Primary bioassay of human myeloma stem cells. J Clin Invest 60:846–854

    Google Scholar 

  • Iselt M, Holtei W, Hilgard P (1989) The tetrazolium dye assay for rapid in vitro assessment of cytotoxicity. Arzneimittelforschung (Drug Res) 39:747–749

    Google Scholar 

  • Schmähl D, Rieseberg T (1956) Resistenz eines neuen Rattentumors gegen Krebs-Chemotherapeutika. Naturwissenschaften 43:475

    Google Scholar 

  • Schumacher W, Respondek J, Engel J, Hitzel-Zerrahn F, Voegeli R, Pohl J, Hilgard P (1989) Synthesis and pharmacological activity of cyclobutane-platinum (II) complexes. In: 22 Hauptversammlung/Gesellschaft Deutscher Chemiker. VCH, Weinheim, p 163

    Google Scholar 

  • Van Glabbecke M, Renard J, Pinedo HM, Cavalli F, Vermoken J, Sessa C, Abele R, Clavel M, Monfardini S (1988) Iproplatin and carboplatin induced toxicities: overview of phase II clinical trial conducted by the EORTC Early Clinical Trials Cooperative Group (ECTG). Eur J Cancer Clin Oncol 24:255–262

    Google Scholar 

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Authors and Affiliations

  1. ASTA Pharma AG, P.O. Box 100105, D-6000, Frankfurt, Federal Republic of Germany

    R. Voegeli, W. Schumacher, J. Engel, J. Respondek & P. Hilgard

Authors
  1. R. Voegeli
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  2. W. Schumacher
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  3. J. Engel
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  4. J. Respondek
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  5. P. Hilgard
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Dedicated to Professor Dr. Dietrich Schmähl on the occasion of his 65th birthday

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Voegeli, R., Schumacher, W., Engel, J. et al. D-19466, a new cyclobutane-platinum complex with antitumor activity. J Cancer Res Clin Oncol 116, 439–442 (1990). https://doi.org/10.1007/BF01612990

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  • DOI: https://doi.org/10.1007/BF01612990

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