Summary
We describe a patient with Whipple's disease without apparent intestinal involvement at initial presentation. Electron microscopy demonstrated the typical bacilli in PAS-negative lymph node and muscle biopsy specimens.
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Comer GM, Brandt LJ, Abissi CJ: Whipple's disease: A review. Am J Gastroenterol 78:107–114, 1983
Bayless TM, Knox DL: Whipple's disease: A multisystem infection. N Engl J Med 300:920–921, 1979
Maizel H, Ruffin JM, Dobbins WO III: Whipple's disease: A review of 19 patients from one hospital and a review of the literature since 1950. Medicine (Baltimore) 49:175–205, 1970
Dobbins WO III, Ruffin JM: A light- and electron microscopic study of bacterial invasion in Whipple's disease. Am J Pathol 51:225–242, 1967
Mansbach CM II, Shelburne JD, Stevens RD, Dobbins WO III: Lymph-node bacilliform bodies resembling those of Whipple's disease in a patient without intestinal involvement. Ann Intern Med 89:64–66, 1978
Sieracki JC, Fine G: Whipple's disease—observations on systemic involvement. II. Gross and histologic observations. Arch Pathol 67:81–93, 1959
Lamberty J, Varela PY, Font RG, Jarvis BW, Coover J: Whipple disease: Light and electron microscopy study. Arch Pathol 98:325–330, 1974
Gross JB, Wollaeger EE, Sauer WG, Huizenga KA, Dahlin DC, Power MH: Whipple's disease: Report of four cases, including two in brothers, with observations on pathologic physiology, diagnosis, and treatment. Gastroenterology 36:65–93, 1959
Wilcox GM, Tronic BS, Schecter DJ, Arron MJ, Righi DF, Weiner NJ: Periodic acid-Schiff-negative granulomatous lymphadenopathy in a patient with Whipple's disease—localization of the Whipple bacillus to noncaseating granulomas by electron microscopy. Am J Med 83:165–170, 1987
Chears WC Jr, Smith AG, Ruffin JM: Diagnosis of Whipple's disease by peripheral lymph node biopsy: Report of a case. Am J Med 27:351–353, 1959
Cho C, Linscheer WG, Hirschkorn MA, Ashutosh K: Sarcoidlike granulomas as an early manifestation of Whipple's disease. Gastroenterology 87:941–947, 1984
Rodarte JR, Garrison CO, Holley KE, Fontana RS: Whipple's disease simulating sarcoidosis: A case with unique clinical and histologic features. Arch Intern Med 129:479–482, 1972
Russo FR: Whipple's disease: Review of the literature and report of two cases. Arch Intern Med 89:600–614, 1952
Pequignot H, Morin Y, Grandjouan S, Guerre J, Liot F, Deslignieres S, Duflo B: Sarcoidose et maladie de Whipple: Association? relation? Ann Med Intern 127:797–806, 1976
Saint-Marc Girardin M-F, Zafrani ES, Chaumette M-T, Delchier J-C, Metreau J-M, Dhumeau D: Hepatic granulomas in Whipple's disease. Gastroenterology 86:753–756, 1984
Rohatgi PK, Singh R, Vieras F: Extrapulmonary localization of gallium in sarcoidosis. Clin Nucl Med 12:9–16, 1987
Sieracki JC: Whipple's disease—observation on systemic involvement: I. Cytologic observation. Arch Pathol 66:464–467, 1958
Oliva H, Gonzalez Campos C, Navarro V, Mogena HH: Two cases of Whipple's disease showing clinical and morphological similarity. Gut 13:430–437, 1972
Torzillo PJ, Bignold L, Khan GA: Absence of PAS-positive macrophages in hepatic and lymphnode granulomata in Whipple's disease. Aust NZ J Med 12:73–75, 1982
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Spapen, H.D.M., Segers, O., de Wit, N. et al. Electron microscopic detection of whipple's bacillus in sarcoidlike periodic acid-Schiff-negative granulomas. Digest Dis Sci 34, 640–643 (1989). https://doi.org/10.1007/BF01536345
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DOI: https://doi.org/10.1007/BF01536345