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Chronic electrical stimulation of the thalamic unspecific activating system in a patient with coma due to midbrain and upper brain stem infarction

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Summary

Chronic intermittent bipolar electrical stimulation of the left nucleus reticulatus polaris thalami was performed in a patient in a state of subcoma due to ischaemic infarction of wide medial parts of the midbrain, mainly the tegmentum, and the right-sided mediobasal parts of the forebrain. Stimulation immediately resulted in autonomic reactions and behavioural arousal reactions during the periods of stimulation. Longterm effect consisted of a rise in the level of clinical responsiveness for a period of seven weeks. A preexistent severe pneumonia disappeared completely after one week of stimulation and returned after seven weeks. The results are discussed on the basis of the pathoanatomical findings and of the physiological functions of the damaged as well as of the stimulated areas.

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Author notes

  1. V. Sturm

    Present address: Neurosurgical Department of the Centre for Surgery, University of Heidelberg, Federal Republic of Germany

Authors and Affiliations

  1. Neurosurgical Department of the Centre for Surgery, University of Heidelberg, Federal Republic of Germany

    A. Kühner & H. Assmus

  2. Neuropathological Department of the Centre for Pathology, University of Heidelberg, Federal Republic of Germany

    H. P. Schmitt

  3. Institute of Physiology, University of Heidelberg, Federal Republic of Germany

    G. Stock

Authors
  1. V. Sturm
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  2. A. Kühner
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  3. H. P. Schmitt
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  4. H. Assmus
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  5. G. Stock
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Additional information

Dedicated to Prof. H. Penzholz on the occasion of his 65th birthday.

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Sturm, V., Kühner, A., Schmitt, H.P. et al. Chronic electrical stimulation of the thalamic unspecific activating system in a patient with coma due to midbrain and upper brain stem infarction. Acta neurochir 47, 235–244 (1979). https://doi.org/10.1007/BF01406406

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