Abstract
The aim of this study was to determine whether hormones mediate the postprandial increase in absorption of water, glucose, and electrolytes that occurs in the canine jejunum. In four dogs, a 75-cm isolated loop of jejunum was extrinsically denervated by autotransplantation. After recovery, the loop was perfused at 2.8 ml/min with an isotonic solution of 130 mM glucose, 80 mM NaCl, and trace amounts of [14C]PEG. Mean transit times through the loop were assessed concurrently with 0.5-ml boluses of [3H]PEG. Experiments were performed during fasting and after an oral meal of 200 g liver. Under steady-state conditions, net absorption of water, glucose, sodium, and chloride was greater after feeding than during fasting. In contrast, mean transit times were nearly identical during fasting and after feeding. We concluded that the augmentation of jejunal absorption of water, glucose, and the electrolytes after feeding was brought about by mechanisms other than alterations in transit time or effects induced via the extrinsic nerves. The augmentation appeared to be mediated, in part, by hormones.
Similar content being viewed by others
References
Sarr MG, Kelly KA, Phillips SF: Canine jejunal absorption and transit during interdigestive and digestive motor states. Am J Physiol 239:G167-G172, 1980
Makhlouf GM: The neuroendocrine design of the gut. Gastroenterology 67:159–184, 1974
Helman CA, Barbezat GO: The effect of gastric inhibitory polypeptide on human jejunal water and electrolyte transport. Gastroenterology 72:376–379, 1979
Krejs GJ, Barkley RM, Read NW, Fordtran JS: Intestinal secretion induced by vasoactive intestinal polypeptide. J Clin Invest 61:1337–1345, 1978
Hicks T, Turnberg LA: The influence of secretin on ion transport in the human jejunum. Gut 14:485–490, 1973
Pansu D, Bosshard A, Vagne M, Mutt V: A fraction isolated from porcine upper small intestine inducing the absorption of water and sodium in duodenum of rats. Scand J Gastroenterol 13 (Suppl 49): 139, 1978 (abstract)
Kachur J, Guandalini S, Field M, Miller RJ: Somatostatin alters intestinal ion transport. Fed Proc 38:427, 1979 (abstract)
Krejs GJ, Brown R, Raskin P: Effect of intravenous somatostatin on jejunal absorption of glucose, amino acids, water, and electrolytes. Gastroenterology 78:26–31, 1980
Akwari OE, Kelly KA, Steinbach JH, Code CF: Electric pacing of intact and transected canine small intestine and its computer model. Am J Physiol 229:1188–1197, 1975
Code CF, Marlett JA: The interdigestive myo-electric complex of the stomach and small bowel of dogs. J Physiol 246:289–309, 1975
Matty AJ, Noble HM: Hormones and water movement through the vertebrate intestine. Hormones 3:42–64, 1972
Field M: Corticosteroids, Na, K-ATPase, and intestinal water and electrolyte transport. Gastroenterology 75:317–319, 1978
Vatner SF, Patrick TA, Higgins CB: Regional circulatory adjustments to eating and digestion in conscious, unrestrained primates. J Appl Physiol 36:524–529, 1974
Burns GP, Schenk WG: Effect of digestion and exercise on intestinal blood flow and cardiac output. Arch Surg 98:790–794, 1969
Chou CC, Hsieh CP, Dabney JM: Comparison of vascular effects of gastrointestinal hormones, on various organs. Am J Physiol 232:H103-H109, 1977
Fara JW, Madden KS: Effect of secretin and cholecystokinin on small intestinal blood flow distribution. Am J Physiol 229:1365–1370, 1975
Lichtenstein B, Winne D: The influence of blood flow on the absorption of 3-O-methylglucose from the jejunum of the rat. Naunyn-Schmiedebergs Arch Pharmacol 279:153–172, 1973
Winne D: The influence of blood flow and water net flux on the absorption of tritiated water from the jejunum of the rat. Naunyn-Schmiedebergs Arch Pharmacol 272:417–436, 1972
Donowitz M, Wicklein D, Reynold DG, Hynes RA, Charney AN, Zinner MJ: Effect of altered intestinal water transport on rabbit ileal blood flow. Am J Physiol 236:H482-H487, 1979
Poitras P, Modigliani R, Bernier J-J: Effect of a combination of gastrin, secretin, cholecystokinin, glucagon and gastric inhibitory polypeptide on jejunal absorption in man. Gut 21:299–304, 1980
Author information
Authors and Affiliations
Additional information
Supported in part by USPHS NIH grants AM18278 and AM7198, and the Mayo Foundation.
Rights and permissions
About this article
Cite this article
Sarr, M.G., Kelly, K.A. & Phillips, S.F. Feeding augments canine jejunal absorption via a hormonal mechanism. Digest Dis Sci 26, 961–965 (1981). https://doi.org/10.1007/BF01314755
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01314755