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Very-low dose antacid in treatment of duodenal ulcer

Comparison with cimetidine

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Abstract

Antacid (AA) in a very low dose (88 mmol/day) was compared to the standard 800-mg dose of cimetidine in healing duodenal ulcers. The influence of sex, age, symptom duration at entry, night pain, smoking, coffee consumption, and alcohol on ulcer healing was studied. The antacid was given in two different schedules: group I-20 ml 1 hr after breakfast and at bedtime; group II-10 ml 1 hr after breakfast and lunch and 20 ml at bedtime. Cimetidine (group III) was given in two divided doses: 400 mg 1 hr after breakfast and 400 mg at bedtime. Endoscopic control was performed after four weeks and, if necessary, after eight weeks of treatment. The healing rate after four weeks of treatment was, respectively, for groups I, II, and III, 45.5%, 55.8%, and 69.4% (group I=group II, and group III different from groups I and II). After eight weeks of treatment the healing rate was 61.5%, 80.8%, and 88.0% for groups I, II, and III, respectively (group II=group III, and group I different from groups II and III). Except for group I, smoking did not influence healing rate. Age, sex, symptoms at entry, night pain, and coffee consumption did not influence the treatment results. The authors concluded that the very low dose of magaldrate (88 mmol/day), when administered in three divided doses (10 ml after breakfast and lunch and 20 ml at bedtime) for eight weeks was as effective as 800 mg of cimetidine (400 mg twice a day) in healing duodenal ulcer.

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Authors and Affiliations

  1. Faculdade de Medicina da Universidade de São Paulo, São Paulo

    S. Zaterka MD, FACG, F. Cordeiro MD, L. G. C. Lyra MD, M. M. Toletino MD, S. J. Miszputen MD, J. L. Jorge MD, E. P. Silva MD, F. E. Vieira MD, J. L. Modena MD, H. K. Massuda MD, J. N. Eisig MD, D. Chinzon MD, A. A. Pereira MD, L. Altieri MD, C. E. Gantois MD, R. B. Wilson MD, M. C. B. Martins MD, H. Rosa MD & E. Dallaverde Neto MD

  2. Hospital Português, Recife

    S. Zaterka MD, FACG, F. Cordeiro MD, L. G. C. Lyra MD, M. M. Toletino MD, S. J. Miszputen MD, J. L. Jorge MD, E. P. Silva MD, F. E. Vieira MD, J. L. Modena MD, H. K. Massuda MD, J. N. Eisig MD, D. Chinzon MD, A. A. Pereira MD, L. Altieri MD, C. E. Gantois MD, R. B. Wilson MD, M. C. B. Martins MD, H. Rosa MD & E. Dallaverde Neto MD

  3. Hospital das Clínicas, Salvador

    S. Zaterka MD, FACG, F. Cordeiro MD, L. G. C. Lyra MD, M. M. Toletino MD, S. J. Miszputen MD, J. L. Jorge MD, E. P. Silva MD, F. E. Vieira MD, J. L. Modena MD, H. K. Massuda MD, J. N. Eisig MD, D. Chinzon MD, A. A. Pereira MD, L. Altieri MD, C. E. Gantois MD, R. B. Wilson MD, M. C. B. Martins MD, H. Rosa MD & E. Dallaverde Neto MD

  4. Unidade de Gastroenterologia, Bauru

    S. Zaterka MD, FACG, F. Cordeiro MD, L. G. C. Lyra MD, M. M. Toletino MD, S. J. Miszputen MD, J. L. Jorge MD, E. P. Silva MD, F. E. Vieira MD, J. L. Modena MD, H. K. Massuda MD, J. N. Eisig MD, D. Chinzon MD, A. A. Pereira MD, L. Altieri MD, C. E. Gantois MD, R. B. Wilson MD, M. C. B. Martins MD, H. Rosa MD & E. Dallaverde Neto MD

  5. Escola Paulista de Medicina, São Paulo

    S. Zaterka MD, FACG, F. Cordeiro MD, L. G. C. Lyra MD, M. M. Toletino MD, S. J. Miszputen MD, J. L. Jorge MD, E. P. Silva MD, F. E. Vieira MD, J. L. Modena MD, H. K. Massuda MD, J. N. Eisig MD, D. Chinzon MD, A. A. Pereira MD, L. Altieri MD, C. E. Gantois MD, R. B. Wilson MD, M. C. B. Martins MD, H. Rosa MD & E. Dallaverde Neto MD

  6. Hospital Celso Ramos, Florianópolis

    S. Zaterka MD, FACG, F. Cordeiro MD, L. G. C. Lyra MD, M. M. Toletino MD, S. J. Miszputen MD, J. L. Jorge MD, E. P. Silva MD, F. E. Vieira MD, J. L. Modena MD, H. K. Massuda MD, J. N. Eisig MD, D. Chinzon MD, A. A. Pereira MD, L. Altieri MD, C. E. Gantois MD, R. B. Wilson MD, M. C. B. Martins MD, H. Rosa MD & E. Dallaverde Neto MD

  7. Hospital Sta. Isabel, Blumenau

    S. Zaterka MD, FACG, F. Cordeiro MD, L. G. C. Lyra MD, M. M. Toletino MD, S. J. Miszputen MD, J. L. Jorge MD, E. P. Silva MD, F. E. Vieira MD, J. L. Modena MD, H. K. Massuda MD, J. N. Eisig MD, D. Chinzon MD, A. A. Pereira MD, L. Altieri MD, C. E. Gantois MD, R. B. Wilson MD, M. C. B. Martins MD, H. Rosa MD & E. Dallaverde Neto MD

  8. Hospital Sta. Joana, Recife

    S. Zaterka MD, FACG, F. Cordeiro MD, L. G. C. Lyra MD, M. M. Toletino MD, S. J. Miszputen MD, J. L. Jorge MD, E. P. Silva MD, F. E. Vieira MD, J. L. Modena MD, H. K. Massuda MD, J. N. Eisig MD, D. Chinzon MD, A. A. Pereira MD, L. Altieri MD, C. E. Gantois MD, R. B. Wilson MD, M. C. B. Martins MD, H. Rosa MD & E. Dallaverde Neto MD

  9. Faculdade de Medicina, Ribeirão Preto

    S. Zaterka MD, FACG, F. Cordeiro MD, L. G. C. Lyra MD, M. M. Toletino MD, S. J. Miszputen MD, J. L. Jorge MD, E. P. Silva MD, F. E. Vieira MD, J. L. Modena MD, H. K. Massuda MD, J. N. Eisig MD, D. Chinzon MD, A. A. Pereira MD, L. Altieri MD, C. E. Gantois MD, R. B. Wilson MD, M. C. B. Martins MD, H. Rosa MD & E. Dallaverde Neto MD

  10. Universidade Federal de Goiás, Goiania

    S. Zaterka MD, FACG, F. Cordeiro MD, L. G. C. Lyra MD, M. M. Toletino MD, S. J. Miszputen MD, J. L. Jorge MD, E. P. Silva MD, F. E. Vieira MD, J. L. Modena MD, H. K. Massuda MD, J. N. Eisig MD, D. Chinzon MD, A. A. Pereira MD, L. Altieri MD, C. E. Gantois MD, R. B. Wilson MD, M. C. B. Martins MD, H. Rosa MD & E. Dallaverde Neto MD

Authors
  1. S. Zaterka MD, FACG
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  2. F. Cordeiro MD
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  3. L. G. C. Lyra MD
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  4. M. M. Toletino MD
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  5. S. J. Miszputen MD
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  6. J. L. Jorge MD
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  7. E. P. Silva MD
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  8. F. E. Vieira MD
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  9. J. L. Modena MD
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  10. H. K. Massuda MD
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  11. J. N. Eisig MD
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  12. D. Chinzon MD
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  13. A. A. Pereira MD
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  14. L. Altieri MD
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  15. C. E. Gantois MD
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  16. R. B. Wilson MD
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  17. M. C. B. Martins MD
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  18. H. Rosa MD
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  19. E. Dallaverde Neto MD
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Zaterka, S., Cordeiro, F., Lyra, L.G.C. et al. Very-low dose antacid in treatment of duodenal ulcer. Digest Dis Sci 36, 1377–1383 (1991). https://doi.org/10.1007/BF01296802

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  • DOI: https://doi.org/10.1007/BF01296802

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