Skip to main content
SpringerLink
Log in

Changes in body temperature markedly affect striatal dopamine release and metabolism: an in vivo study

  • Full Papers
  • Published:
Journal of Neural Transmission / General Section JNT Aims and scope Submit manuscript

Summary

Dopamine release and metabolism in the corpus striatum increased markedly when the core body temperature of anesthetized rats was increased from 35 ° to 41 °C while temperatures below 34 ° were associated with a marked attenuation of dopamine release. These observations may have clinical relevance in cases where alterations in body temperature are associated with extrapyramidal dysfunction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Brannan T, Bhardwaj A, Martínez-Tica J, Weinberger J, Yahr M (1990) Striatal L-dopa metabolism studied in vivo in rats with nigrostriatal lesions. J Neural Transm [P-D Sect] 2: 15–22

    Google Scholar 

  • Busto R, Dietrich WD, Globus MY-T, Valdés I, Scheinberg P, Ginsberg MD (1987) Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 7: 729–738

    Google Scholar 

  • Ebadi M, Pfeiffer RF, Murrin LC (1990) Pathogenesis and treatment of neuroleptic malignant syndrome. Gen Pharmacol 21: 367–386

    Google Scholar 

  • Henderson VW, Wooten GF (1981) Neuroleptic malignant syndrome: a pathogenic role for dopamine receptor blockade? Neurology 31: 132–137

    Google Scholar 

  • Montgomery JC, MacDonald JA (1990) Effects of temperature on nervous system: implications for behavioural performance. Am J Physiol 259: R 191-R 196

    Google Scholar 

  • Sechi GP, Tanda F, Mutani R (1984) Fatal hyperpyrexia after withdrawal of levodopa. Neurology 34: 249–251

    Google Scholar 

  • Slivka A, Brannan TS, Weinberger J, Knott PJ, Cohen G (1988) Increase in extracellular dopamine in the striatum during cerebral ischemia: a study utilizing cerebral microdialysis. J Neurochem 50: 1714–1718

    Google Scholar 

  • Stahle L (1989) Effects of body temperature on brain extracellular dopamine in microdialysis experiments in the anesthetized rat. Current Separations 9: 65–66

    Google Scholar 

Download references

Author information

Author notes

  1. T. Brannan

    Present address: Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA

Authors and Affiliations

  1. Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA

    J. Martínez-Tica & M. D. Yahr

Authors
  1. T. Brannan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Martínez-Tica
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. D. Yahr
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brannan, T., Martínez-Tica, J. & Yahr, M.D. Changes in body temperature markedly affect striatal dopamine release and metabolism: an in vivo study. J. Neural Transmission 89, 193–196 (1992). https://doi.org/10.1007/BF01250671

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01250671

Keywords

Search

Navigation