Summary
SKF 38393, a selective D-1 dopamine receptor agonist, elevated plasma prolactin levels in eight patients with various neurological disorders. Growth hormone concentrations were unaffected by SKF 38393 administration. The results suggest that D-1 receptors may be involved in the regulation of prolactin secretion.
Similar content being viewed by others
References
Ahn SH, Gardner E, Makman MH (1979) Anterior pituitary adenylate cyclase: stimulation by dopamine and other monoamines. Eur J Pharmacol 53: 313–317
Apud JA, Masotto C, Ongini E, Racagni G (1985) Interaction of SCH 23390, a D-1-selective antagonist, with the anterior pituitary D-2 receptors and prolactin secretion in the rat. Eur J Pharmacol 112: 187–193
Barone P, Davis TA, Braun AR, Chase TN (1986) Dopaminergic mechanisms and motor function: characterization of D-1 and D-2 receptor interaction. Eur J Pharmacol 123: 109–114
Ben-Jonathan N, Olivier C, Weiner HJ, Mical RS, Porter JC (1977) Dopamine in hypophyseal portal plasma of the rat during the estrous cycle and throughout pregnancy. Endocrinology 100: 452–458
Boyson SJ, McGonigle P, Molinoff PB (1986) Quantitative autoradiographic localization of D-1 and D-2 subtypes of dopamine receptors in rat brain. J Neurol Sci 6: 3177–3188
Braun AR, Barone P, Chase TN (1986) Interaction of D-1 and D-2 dopamine receptors in the expression of dopamine agonist induced behaviors. In: Breese GR, Creese I (eds) Neurobiology of central D-1 dopamine receptors. Plenum Press, New York, pp 151–166
Braun A, Fabbrini G, Mouradian MM, Serrati C, Barone P, Chase TN (1987) Selective D-1 dopamine receptor agonist treatment of Parkinson's disease. J Neural Transm 68: 41–50
Denef C, Manet D, Dewals R (1980) Dopaminergic stimulation of prolactin release. Nature 285: 243–246
Eddy RL, Jones AL, Chakmakjian ZH, Silverthorne MC (1971) Effect of levodopa on human hypophyseal trophic hormone release. J Clin Endocrinol 33: 709–712
Enjalbert A, Bockaert J (1983) Pharmacological characterization of the D-2 dopamine receptor negatively coupled with adenylate cyclase in rat anterior pituitary. Mol Pharmacol 23: 576–584
Kebabian JW, Calne DB (1979) Multiple receptors for dopamine. Nature 277: 93–96
Iorio LC, Barnett A, Leitz FH, Houser VP, Korduba CA (1983) SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems. J Pharmacol Exp Ther 226: 462–468
Saller CF, Salama AI (1985) Dopamine receptor subtypes: in vivo biochemical evidence for functional interaction. Eur J Pharmacol 109: 297–300
Saller CF, Salama AI (1986a) D-1 dopamine receptor stimulation elevates plasma prolactin levels. Eur J Pharmacol 122: 139–142
Saller CF, Salama AI (1986b) D-1 and D-2 dopamine receptor blockade: interactive effects in vitro and in vivo. J Pharmacol Exp Ther 236: 714–720
Setler PE, Sarau HM, Zirkle CL, Saunders HL (1978) The central effects of a novel dopamine agonist. Eur J Pharmacol 50: 419–430
Stoof JC, Kebabian JW (1981) Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum. Nature 294: 366–368
Swennen L, Denef C (1982) Physiological concentrations of dopamine decrease adenosine 3′,5′-monophosphate levels in cultured rat anterior pituitary cells and enriched populations of lactotrophs: evidence for a causal relationship to inhibition of prolactin release. Endocrinology 111: 398–405
Tanimoto K, Tamminga CA, Chase TN (1987) Elevation in plasma prolactin concentrations by SCH 23390 and SKF 38393 in freely moving rats. Eur J Pharmacol, in press
Titeler M, Van Loon GR, Seeman P, Brown GM (1981) D-2 but no D-3 dopamine receptors detected in the anterior pituitary. Eur J Pharmacol 71: 143–146
Weiner RI, Ganong WF (1978) Role of brain monoamines and histamine in regulation of anterior pituitary secretion. Physiol Rev 58: 905–976
Weinstock J, Hieble JP, Wilson JW (1985) The chemistry and pharmacology of 3-benzazepine derivatives. Drugs Future 10: 645–697
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fabbrini, G., Braun, A., Mouradian, M.M. et al. Dopamine D-1 receptor agonist stimulation of prolactin secretion in man. J. Neural Transmission 71, 159–163 (1988). https://doi.org/10.1007/BF01245709
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01245709