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Dopamine D-1 receptor agonist stimulation of prolactin secretion in man

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Summary

SKF 38393, a selective D-1 dopamine receptor agonist, elevated plasma prolactin levels in eight patients with various neurological disorders. Growth hormone concentrations were unaffected by SKF 38393 administration. The results suggest that D-1 receptors may be involved in the regulation of prolactin secretion.

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References

  • Ahn SH, Gardner E, Makman MH (1979) Anterior pituitary adenylate cyclase: stimulation by dopamine and other monoamines. Eur J Pharmacol 53: 313–317

    Google Scholar 

  • Apud JA, Masotto C, Ongini E, Racagni G (1985) Interaction of SCH 23390, a D-1-selective antagonist, with the anterior pituitary D-2 receptors and prolactin secretion in the rat. Eur J Pharmacol 112: 187–193

    Google Scholar 

  • Barone P, Davis TA, Braun AR, Chase TN (1986) Dopaminergic mechanisms and motor function: characterization of D-1 and D-2 receptor interaction. Eur J Pharmacol 123: 109–114

    Google Scholar 

  • Ben-Jonathan N, Olivier C, Weiner HJ, Mical RS, Porter JC (1977) Dopamine in hypophyseal portal plasma of the rat during the estrous cycle and throughout pregnancy. Endocrinology 100: 452–458

    Google Scholar 

  • Boyson SJ, McGonigle P, Molinoff PB (1986) Quantitative autoradiographic localization of D-1 and D-2 subtypes of dopamine receptors in rat brain. J Neurol Sci 6: 3177–3188

    Google Scholar 

  • Braun AR, Barone P, Chase TN (1986) Interaction of D-1 and D-2 dopamine receptors in the expression of dopamine agonist induced behaviors. In: Breese GR, Creese I (eds) Neurobiology of central D-1 dopamine receptors. Plenum Press, New York, pp 151–166

    Google Scholar 

  • Braun A, Fabbrini G, Mouradian MM, Serrati C, Barone P, Chase TN (1987) Selective D-1 dopamine receptor agonist treatment of Parkinson's disease. J Neural Transm 68: 41–50

    Google Scholar 

  • Denef C, Manet D, Dewals R (1980) Dopaminergic stimulation of prolactin release. Nature 285: 243–246

    Google Scholar 

  • Eddy RL, Jones AL, Chakmakjian ZH, Silverthorne MC (1971) Effect of levodopa on human hypophyseal trophic hormone release. J Clin Endocrinol 33: 709–712

    Google Scholar 

  • Enjalbert A, Bockaert J (1983) Pharmacological characterization of the D-2 dopamine receptor negatively coupled with adenylate cyclase in rat anterior pituitary. Mol Pharmacol 23: 576–584

    Google Scholar 

  • Kebabian JW, Calne DB (1979) Multiple receptors for dopamine. Nature 277: 93–96

    Google Scholar 

  • Iorio LC, Barnett A, Leitz FH, Houser VP, Korduba CA (1983) SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems. J Pharmacol Exp Ther 226: 462–468

    Google Scholar 

  • Saller CF, Salama AI (1985) Dopamine receptor subtypes: in vivo biochemical evidence for functional interaction. Eur J Pharmacol 109: 297–300

    Google Scholar 

  • Saller CF, Salama AI (1986a) D-1 dopamine receptor stimulation elevates plasma prolactin levels. Eur J Pharmacol 122: 139–142

    Google Scholar 

  • Saller CF, Salama AI (1986b) D-1 and D-2 dopamine receptor blockade: interactive effects in vitro and in vivo. J Pharmacol Exp Ther 236: 714–720

    Google Scholar 

  • Setler PE, Sarau HM, Zirkle CL, Saunders HL (1978) The central effects of a novel dopamine agonist. Eur J Pharmacol 50: 419–430

    Google Scholar 

  • Stoof JC, Kebabian JW (1981) Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum. Nature 294: 366–368

    Google Scholar 

  • Swennen L, Denef C (1982) Physiological concentrations of dopamine decrease adenosine 3′,5′-monophosphate levels in cultured rat anterior pituitary cells and enriched populations of lactotrophs: evidence for a causal relationship to inhibition of prolactin release. Endocrinology 111: 398–405

    Google Scholar 

  • Tanimoto K, Tamminga CA, Chase TN (1987) Elevation in plasma prolactin concentrations by SCH 23390 and SKF 38393 in freely moving rats. Eur J Pharmacol, in press

  • Titeler M, Van Loon GR, Seeman P, Brown GM (1981) D-2 but no D-3 dopamine receptors detected in the anterior pituitary. Eur J Pharmacol 71: 143–146

    Google Scholar 

  • Weiner RI, Ganong WF (1978) Role of brain monoamines and histamine in regulation of anterior pituitary secretion. Physiol Rev 58: 905–976

    Google Scholar 

  • Weinstock J, Hieble JP, Wilson JW (1985) The chemistry and pharmacology of 3-benzazepine derivatives. Drugs Future 10: 645–697

    Google Scholar 

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Fabbrini, G., Braun, A., Mouradian, M.M. et al. Dopamine D-1 receptor agonist stimulation of prolactin secretion in man. J. Neural Transmission 71, 159–163 (1988). https://doi.org/10.1007/BF01245709

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  • DOI: https://doi.org/10.1007/BF01245709

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