Summary
Plasma insulin values during a 50 g. oral glucose tolerance test were measured by immuno-assay in 34 control subjects. Peak insulin levels occurred within the first 60 minutes and the fasting level was approached by 120 minutes. The insulin curve closely resembled the blood sugar curve and a significant correlation was found between the blood sugar and plasma insulin values at 60, 90 and 120 minutes after oral glucose. The results suggest that the wide range in plasma insulin response is due in part at least to variations in the blood sugar. The results also tend to confirm that immuno-reactive insulin is biologically significant.
Résumé
On a mesuré les valeurs de l'insuline plasmatique, à l'aide du dosage immunologique, pendant un test de tolérance à 50 g de glucose administré par voie orale, chez 34 sujets témoins. Les taux maximums d'insuline se situaient dans les 60 premières minutes, et à 120 minutes les taux étaient proches de ceux à jeun. La courbe de l'insuline ressemblait étroitement à la courbe de la glycémie et on a trouvé une relation significative entre les valeurs de la glycémie et de l'insuline plasmatique, 60, 90 et 120 minutes après l'administration orale de glucose. Les résultats suggèrent que la large bande de variations dans la réponse de l'insuline plasmatique est due, au moins en partie, aux variations de la glycémie. Les résultats tendent également à confirmer que l'insuline immunoréactive est biologiquement significative.
Zusammenfassung
Die Plasma-Insulinwerte während der oralen Glukosebelastung mit 50 g Glukose wurden bei 34 Normalpersonen immunologisch gemessen. Die Höchstwerte wurden innerhalb der ersten 60 Minuten erreicht, nach 120 Minuten näherten sich die Spiegel wieder dem Nüchternwert. — Die Insulinkurve ähnelte der Blutzuckerkurve stark. Wir fanden eine signifikante Korrelation zwischen Blutzucker- und Plasmainsulinwerten 60, 90 und 120 Minuten nach der oralen Glukosezufuhr. Die Ergebnisse deuten darauf hin, daß die starken Unterschiede in der Insulinausschüttung zum Teil durch Schwankungen der Blutzuckerwerte bedingt sind. Sie stützen ferner die Anschauung, daß das immunologisch nachweisbare Insulin biologische Bedeutung hat.
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Buchanan, K.D., McKiddie, M.T. The normal insulin response to glucose. Diabetologia 3, 460–464 (1967). https://doi.org/10.1007/BF01228083
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DOI: https://doi.org/10.1007/BF01228083