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Organic synthesis on the microgram scale. IX

Acetylation of aromatic amines: Microanalysis by attenuated total reflectance

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Summary

Synthesis of acetanilide and analogs in good yields has been carried out inμg amounts by reacting the aromatic amines with an acetic anhydride-acetic acid mixture. After TLC separation on the same vehicle, the products can be visualized by ultraviolet radiation or by color reactions. A procedure is also described to recover the acetanilides for obtaining infrared spectra by the attenuated total reflection technique.

Zusammenfassung

Die Synthese von Acetanilid und analogen Substanzen wurde mit guter Ausbeute in Mikrogrammengen durchgeführt. Man läßt das aromatische Amin mit einer Mischung von Acetanhydrid und Essigsäure reagieren. Nach DC-Trennung in diesem Laufmittel kann man die Reaktionsprodukte im UV oder durch eine Farbreaktion sichtbar machen. Außerdem wurde ein Verfahren beschrieben, die Acetanilide für die IR-Spektroskopie nach der ATR-Methode wiederzugewinnen.

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Authors and Affiliations

  1. Department of Chemistry, City University of New York, 11210, Brooklyn, N. Y., USA

    Jerry Polesuk & T. S. Ma

  2. Division of Sandoz-Wander, Inc., Sandoz Pharmaceuticals, 07936, East Hanover, N. J., USA

    Jerry Polesuk

Authors
  1. Jerry Polesuk
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  2. T. S. Ma
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Additional information

For Part VIII see Mikrochim. Acta [Wien]1971, 662.

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Polesuk, J., Ma, T.S. Organic synthesis on the microgram scale. IX. Microchim Acta 60, 313–320 (1972). https://doi.org/10.1007/BF01219824

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  • DOI: https://doi.org/10.1007/BF01219824

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