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Oxidation of analgin with triphenyltetrazolium chloride and chromatographic study of the products of the reaction

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Summary

In alkaline solution triphenyltetrazolium chloride (TTC) oxidizes analgin to 4-methylaminoantipyrine. The products of the reaction were identified chromatographically. The systemsn-butanol-acetic acid-water (4∶1∶5) and pentanol-acetic acid-water (4∶1∶5) were used as mobile phases. Dragendorff's reagent was used for detection. It was proved that the principal end-products of the oxidation of analgin with TTC are 4-methylaminoantipyrine and triphenylformazan.

Zusammenfassung

In alkalischer Lösung oxydiert Triphenyltetrazoliumchlorid (TTC) Analgin zu 4-Methylaminoantipyrin. Die Reaktionsprodukte wurden chromatographisch identifiziert. Die Systeme n-Butanol: Essigsäure: Wasser (4∶1∶5) und Pentanol∶Essigsäure∶Wasser (4∶1∶5) wurden als mobile Phase verwendet. Zum Nachweis diente Dragendorffs Reagens. Als hauptsächliche Endprodukte wurden 4-Methylamino-antipyrin und Triphenylformazan erwiesen.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Institute of Food Industry, Plovdiv, Bulgaria

    P. Yassileva-Alexandrova

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  1. P. Yassileva-Alexandrova
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Yassileva-Alexandrova, P. Oxidation of analgin with triphenyltetrazolium chloride and chromatographic study of the products of the reaction. Mikrochim Acta 59, 471–475 (1971). https://doi.org/10.1007/BF01219054

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  • DOI: https://doi.org/10.1007/BF01219054

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