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Pancreatic endocrinomas: A statistical analysis of 1,857 cases

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Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

A total of 1857 cases of pancreatic endocrinomas and related pathological disorders producing gut-pancreatic hormones were collected from the world literature and were statistically analyzed and evaluated. The entire series in the present study consisted primarily of histologically confirmed islet cell tumors, but included 30 cases of vasoactive intestinal peptide (VIP)-producing neurogenic tumors and 54 cases of islet hyperplasia, the former being excluded from the systematic evaluation. The series consisted of seven groups: (1) gastrinomas/Zollinger-Ellison syndrome (ZES), (2) somatostatinomas, (3) glucagonomas/diabetes-dermatitis syndrome (DDS), (4) insulinomas/hypoglycemic syndrome (HGS), (5) vipomas/watery diarrhea hypokalemia achlorhydria (WDHA) syndrome, (6) pancreatic polypeptide (PP)-producing tumors (PPomas), and (7) miscellaneous endocrinomas. The statistical analysis dealt mainly with the location, male/female ratio, age distribution, clinical and pathological features, multiplicity, and malignant nature of pancreatic endocrinomas. The delineating of 52 PPomas in this series, and confirmation of the tumor entity by radioimmunoassay and immunocytochemical procedures, were matters of special emphasis in this study.

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Authors and Affiliations

  1. College of Biomedical Technology, Niigata University, Asahimachi-dori 2-746, 951, Niigata City, Japan

    Jun Soga & Yasuko Yakuwa

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  1. Jun Soga
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  2. Yasuko Yakuwa
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Soga, J., Yakuwa, Y. Pancreatic endocrinomas: A statistical analysis of 1,857 cases. J Hep Bil Pancr Surg 1, 522–529 (1994). https://doi.org/10.1007/BF01211914

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  • DOI: https://doi.org/10.1007/BF01211914

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