Abstract
A case of primary Hodgkin's disease, a lymphocyte-predominant entity, occurring in the stomach is described. The patient was a 37-year-old man who complained of general fatigue. Endoscopic biopsy revealed gastric malignant lymphoma. Subtotal gastrectomy and postoperative chemotherapy following a modifid CHOP regimen were performed. The patient has been free of recurrence during a follow-up period of 15 months. The preoperative diagnosis of gastric Hodgkin's disease is difficult. Thus far, of 100 cases of gastric Hodgkin's disease reported in Japan, only 3 were diagnosed correctly preoperatively. We also misdiagnosed our case, as B cell type malignant lymphoma, preoperatively. The final diagnosis of Hodgkin's disease of the stomach was made on the basis of histopathological and immunohistochemical examinations. Hodgkin's disease of the stomach is rare, and there are histologically similar diseases; Ki-1 lymphoma, adult T cell lymphoma, malignant hystiocytosis, and infectious monocytosis. Careful diagnosis is essential thus for Hodgkin's disease of the stomach.
Similar content being viewed by others
References
Brooks JJ, Enterline HT. Primary gastric lymphomas: A clinicopathologic study of 58 cases with long-term follow up and literature review. Cancer 1983;51:701–711.
Takagi K, Yamamoto H, Kishimoto H, et al. Malignant lymphoma of the stomach: Surgical treatment and its results (in Japanese with English abstract). I to Cho (Stomach and Intestine) 1981;16:493–501.
Nakano Y, Shiozaki H, Matuura N, et al. A case report of Hodgkin's disease of the stomach and the spleen (in Japanese). J Clin Surg 1984;39:1463–1466.
Stein H, Mason DY, Gerdes N, et al. The expression of the Hodgkin's disease-associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: Evidence that Reed-Sternberg cells and hystioctytic malignancies are derived from activated lymphoid cells. Blood 1985;66:848–858.
Nakanuma Y, Kuruyama H, Kurashima K. An autopsy case of malignant histocytosis with Reed-Sternberg-like cells. Acta Pathol Jap 1989;39:79–83.
Tsurmi H, Takahashi T, Moriwaki H, et al. CD30/Ki-1-positive anaplastic large cell lymphoma preceded by Hodgkin's disease. Int J Hematol 1992;56:99–102.
Hashimoto K, Ikeda H, Sumitsuji S, et al. Adult T-cell leukemia/ lymphoma, histologically presenting Ki-1-positive anaplastic large cell lymphoma (in Japanese with English abstract). Jpn J Clin Hematol 1992;33:1725–1729.
Schwab U, Stein H, Gerdes J, et al. Production of a monoclonal antibody specific for Hodgkin and Reed-Sternberg cells of Hodgkin's disease and a subset of normal lymphoid cells. Nature 1982;299:65–67.
Hus S-M, Jaffe ES. Leu M1 and peanut agglutinin stain the neoplastic cells of Hodgkin's disease. Am J Clin Pathol 1984;82:29–32.
Delson G, Saati TA, Gatter KC, et al. Coexpression of epithelial membrane antigen (EMA), Ki-1, and interleukin-2 receptor by anaplastic large cell lymphomas. Am J Pathol 1988;130:59–70.
Tsang WYW, Chan JKC, Ng CS. The nature of Reed-Sternberglike cells in chronic lymphocytic leukemia. Am J Clin Pathol 1993;99:317–323.
Frizzera G. The distinction of Hodgkin's disease from anaplastic large cell lymphoma. Semin Diagn Pathol 1992;9:291–296.
Rosso R, Pauli M, Magrini U, et al. Anaplastic large cell lymphoma, CD30/Ki-15 positive, expressing the CD15/Leu-Ml antigen: Immunohistochemical and morphological relationships to Hodgkin's disease. Virchows Arch [A] 1990;416:229–235.
Dowson IMP, Cornes JS, Morson BC. Primary malignant lymphoid tumors of the intestinal tract. Br J Surg 1961;49:80–89.
Naquvi MS, Burrows L, Kark AE. Lymphoma of the gastrointestinal tract. Prognostic guides based on 162 cases. Ann Surg 1969:170:221–231.
Soderstrom KO, Joensuu H. Primary Hodgkin's disease of the stomach. Am J Clin pathol 1988;89:806–809.
Boiocchi M, Re VD, Gloghini A, et al. High incidence of monoclonal EBV epitomes in Hodgkin's disease and anaplastic large-cell Ki-1-positive lymphomas in HIV-1-positive patients. Int J Cancer 1993;54:53–59.
Geboes K, Bossaert H, Dooms MT, et al. Primary Hodgkin's disease of the stomach in a 72-year-old man. J Am Geriatr Soc 1980;28:71–75.
Oshima S, Nakahara H, Sakamoto M, et al. A case of gastric Hodgkin's disease (in Japanese). J Jpn Soc Clin Surg 1979;42:406–413.
Matsumoto H, Masamune O, Nunode Y, et al. A case of malignant lymphoma (Hodgkin's disease) in the stomach with hypoproteinemia (in Japanese). Jpn J Gastroenterol 1982;79:983–987.
Oku K, Tsuhada K, Osawa Y, et al. A case report of Hodgkin's disease of the stomach (in Japanese with English abstract). Arch Jpn Chir 1978;47:483–488.
Allen AW, Donaldoson G, Sniffen RC, et al. Primary malignant lymphoma of the gastrointestinal tract. Am Surg 1954;140:428–438.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ogawa, Y., Chung, Y.S., Nakata, B. et al. A case of primary Hodgkin's disease of the stomach. J Gastroenterol 30, 103–107 (1995). https://doi.org/10.1007/BF01211383
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01211383