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Brief report: Low frequency of the fragile X syndrome among Japanese autistic subjects

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Conclusion

The prevalence of Fra(X) among infantile autism in Japanese subjects was found to be no higher than in subject groups having nonspecific metal retardation, and thus it is concluded that Fra(X) does not constitute an etiologically valid autism subgroup.

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References

  • American Psychiatric Association. (1980).Diagnostic and statistical manual of mental disorders (3rd ed.) Washington, DC: Author.

    Google Scholar 

  • Arinami, T., & Kondou, I. (1986). The fragile X syndrome in a Japanese population of institutionalized mentally retarded males. [in Japanese]Seishin Igaku, 28, 946–948.

    Google Scholar 

  • Blomquist, H. K., Gustavson, K-H., Holmgren, G., Nordenson, I., & Polsson-Stree, U. (1983). Fragile X syndrome in mildly mentally retarded children in a northern Swedish country: A prevalence study.Clinical Genetics, 24, 393–398.

    Google Scholar 

  • Blomquist, H. K., Bohman, M., Edvinsson, S. O., Gillberg, C., Gustavson, K-H., Holmgren, G., & Wahlström, J. (1985). Frequency of the fragile X syndrome in infantile autism: A Swedish multicenter study.Clinical Genetics, 27, 113–117.

    Google Scholar 

  • Bregman, J. D., Dykens, E., Watson, M., Ort, S. I., & Leekman, J. F. (1987). Fragile X syndrome: Variability of phenotypic expression.Journal of the American Academy of Child and Adolescent Psychiatry, 26, 463–471.

    Google Scholar 

  • Bregman, J. D., Leckman, J. F., & Ort, S. I. (1988). Fragile X syndrome: genetic preposition to psychopathology.Journal of Autism and Developmental Disorders, 18, 343–345.

    Google Scholar 

  • Brown, W. T., Jenkins, E. C., Friedman, E., Judith, B., Winsniewski, K., Raguthu, S., & French, J. (1982). Autism is associated with the fragile-X syndrome.Journal of Autism and Developmental Disorders, 12, 303–308.

    Google Scholar 

  • Brown, W. T., Jenkins, E. C., Cohen, I. L., Fisch, G. S., Wolf-Schein, E. G., Gross, A., & Waterhouse, L. (1986). Fragile X and autism: A multicenter survey.American Journal of Medical Genetics, 23, 341–352.

    Google Scholar 

  • Einfeld, S., Monoly, H., & Hall, W. (1989). Autism is not associated with the fragile X sybdrome.American Journal of Medical Genetics, 34, 187–193.

    Google Scholar 

  • Fisch, G. S., Cohen, I. L., Wolf, E. G., Brown, W. T., Jenkins, E. C., & Gross, A. (1986). Autism and the fragile X syndrome.American Journal of Psychiatry, 143, 71–73.

    Google Scholar 

  • Fisch, G. S., Cohen, I. L., Gross, A. C., Jenkins, V., Jenkins, E. C., & Brown, W. T. (1988). Folic acid treatment of fragile X males: A further study.American Journal of Medical Genetics, 30, 393–399.

    Google Scholar 

  • Fisch, G. S., Cohen, I. L., Jenkins, E. C., & Brown, W. T. (1988). Screening developmentally disabled male population for fragile X: The effect of sample size.American Journal of Medical Genetics, 30, 655–663.

    Google Scholar 

  • Folstein, S., & Rutter, M. (1977). Infantile autism: A genetic study of 21 twin pairs.Journal of Child Psychology and Psychiatry, 18, 297–321.

    Google Scholar 

  • Froster-Iskenius, U., Felch, G., Schirren, C., & Schwinger, E. (1983). Screening for fra(X)(q) in a population of mentally retarded males.Human Genetics, 63, 153–157.

    Google Scholar 

  • Goldfine, P. E., McPherson, P. M., Heath, G. A., Hardesty, V. A., Beauregard, L. J., & Gordon, B. (1985). Association of fragile X syndrome with autism.American Journal of Psychiatry, 142, 108–110.

    Google Scholar 

  • Hagerman, R. J., Jackson, A. W., Levitas, A., Rimland, B., & Braden, M. (1986). An analysis of autism in fifty males with the fragile X syndrome.American Journal of Medical Genetics, 23, 359–374.

    Google Scholar 

  • Ho, H. H. & Kalousek, D. K. (1989). Brief report: Fragile X syndrome in autistic boys.Journal of Autism and Developmental Disorders, 19, 343–347.

    Google Scholar 

  • Jorgensen, O. S., Nielsen, K. B., Isager, T., & Mouridsen, S. E. (1984). Fragile X-chromosome among child psychiatric patients with disturbance of language and social relationships.Acta Psychiatrica Scandinavica, 70, 510–514.

    Google Scholar 

  • Judd, L. L., & Mandell, A. J. (1968). Chromosome studies in early infantile autism.Archives of General Psychiatry, 18, 450–457.

    Google Scholar 

  • Lejeune, J. (1982). Is the fragile X syndrome amenable to treatment?Lancet, 1, 273–274.

    Google Scholar 

  • Madokoro, H., Ohdo, S., Sonoda, T., Ohba, K., Tanaka, H., & Hayakawa, K. (1989). Infantile autism and the fragile X syndrome in Japanese children.Acta Paediatrica Japonica, 31, 163–165.

    Google Scholar 

  • Matuishi, T., Shiotuki, Y., Niikawa, N., Karafuchi, Y., Otaki, E., Ando, H., Yamashita, Y., Horikawa, M., Urabe, F., Kuriya, N., & Yamashita, F. (1987). Fragile X syndrome in Japanese patients with infantile autism.Pediatric Neurology, 3, 284–287.

    Google Scholar 

  • McGillivery, B. C., Herbst, D. S., Dill, F. J., Sandercock, H. J., & Tischler, B. (1986). Infantile autism: An occasional manifestation of fragile(X) mental retardation.American Journal of Medical Genetics, 23, 353–358.

    Google Scholar 

  • Niikawa, N. (1986). Fragile X syndrome (fragile X-linked mental retardation; Martin-Bell Syndrome): (2) cytogenetic and genetic aspect. [in Japanese]Japanese Journal of Clinical and Experimental Medicine (IGAKU NO AYUMI), 137, 600–603.

    Google Scholar 

  • Payton, J. B., Steele, M. W., Wenger, S. L., & Minshew, N. J. (1989). The fragile X marker and autism in perspective.Journal of the American Academy of Child and Adolescent Psychiatry, 28, 417–421.

    Google Scholar 

  • Primrose, D. A., El-Matmati, R., Boyd, E., Gosden, C., & Newton, M. (1986). Prevalence of the fragile X syndrome in an institution for the mentally handicapped.British Journal of Psychiatry,148, 655–657.

    Google Scholar 

  • Pueschel, S. M., Herman, R., & Groden, G. (1985). Brief report: Screening children with autism for fragile-X syndrome and phenyketonuria.Journal of Autism and Developmental Disorders, 15, 335–338.

    Google Scholar 

  • Reis, Von, A. S. (1986). Infantiler Autismus und Marker-X-Syndrom.Sozialp Diatrie, 8, 612–616.

    Google Scholar 

  • Reiss, A. L., & Freund, L. (1990). Fragile X syndrome, DSM-III-R, and Autism.Journal of the American Academy of Child and Adolescent Psychiatry, 29, 885–891.

    Google Scholar 

  • Ritvo, E. R., Freeman, B. J., Mason-Brothers, A., Mo, A., & Ritvo, A. M. (1985). Concordance for the syndrome of autism in 40 pairs of afflicted twins.American Journal of Psychiatry, 142, 74–77.

    Google Scholar 

  • Rutter, M. (1978). Diagnosis and definition of childhood autism.Journal of Autism and Developmental Disorders, 8, 139–161.

    Google Scholar 

  • Sutherland. G. R. (1982). Heritable fragile sites on human chromosomes. VIII. Preliminary population cytogenetic data on the folic-acid-sensitive fragile sites.American Journal of Human Genetics, 34, 452–458.

    Google Scholar 

  • Venter, P. A., Hof, J. O., & Coetzee, D. J. (1986). The Martin-Bell syndrome in South Africa.American Journal of Medical Genetics, 23, 597–610.

    Google Scholar 

  • Wahlström, J., Gillberg, C., Gustavson, K. H., & Holmgren, G. (1986). Infantile autism and the fragile X: A swedish multicenter study.American Journal of Medical Genetics, 23, 403–408.

    Google Scholar 

  • Watson, M. S., Leckman, J. F., Annex, B., Breg, W. R., Boles, D., Volkmar, F. R., Cohen, D. J., & Carter, C. (1984). Fragile X in a survey of 75 autistic males.New England Journal of Medicine, 310, 1462.

    Google Scholar 

  • Webb, T. P., Bundey, S. E., Thake, A. I., & Todd, J. (1986). Population incidence and segregation ratios in the Martin-Bell syndrome.American Journal of Medical Genetics, 23, 573–580.

    Google Scholar 

  • Wilson, J. D., Braunwald, E., Isselbacher, K. J., Petersdorf, R. G., Martin, J. B., Facci, A. S., & Root, R. K. (Eds.). (1990).The practice of medicine. InHarrison's principles of internal medicine (12th ed.). New York: McGraw-Hill.

    Google Scholar 

  • World Health Organization. (1988).International classification of disease (10th rev., Chap. 5, draft). Geneva: Author.

    Google Scholar 

  • Wright, H. H., Young, S. R., Edwards, J. G., Abramson, R. K., & Duncan, J. (1986). Fragile X syndrome in population of autistic children.Journal of the American Academy of Child Psychiatry, 25, 641–644.

    Google Scholar 

  • Yokoyama, Y., Takahashi, K., Horigome, A., & Takahashi, M. (1980). The fragile X Chromosome. [in Japanese]Japanese Journal of Clinical Pathology, 129–137.

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Authors and Affiliations

  1. Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan

    Ohiko Hashimoto

  2. Yokohama Rehabilitation Center, Yokohama, Japan

    Yasuo Shimizu

  3. Tokyo Metropolitan Tama Habilitation Clinic, Tokyo, Japan

    Yoko Kawasaki

Authors
  1. Ohiko Hashimoto
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  2. Yasuo Shimizu
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  3. Yoko Kawasaki
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Hashimoto, O., Shimizu, Y. & Kawasaki, Y. Brief report: Low frequency of the fragile X syndrome among Japanese autistic subjects. J Autism Dev Disord 23, 201–209 (1993). https://doi.org/10.1007/BF01066429

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