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Toxicity of metabolites of dieldrin, photodieldrin, and endrin in the cockroach

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Abstract

Major metabolic products of dieldrin, endrin, and photodieldrin were identified in the American cockroach, and their toxicities were tested in the male German cockroach. Among dieldrin metabolites tested, F-1 the major fecal metabolite in rats, was most toxic to the German cockroach. The most toxic metabolite of endrin was 3-hydroxyendrin. The toxic endrin metabolite to the rat, 12-ketoendrin, was not so toxic to the German cockroach. The most consistent major metabolic product of photodieldrin, U-1, which is identical to the major urinary metabolite in the rat, was less toxic and slower-acting than photodieldrin against the German cockroach, indicating that this major metabolic product is not the actual toxicant in this species.

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Kadous, A.A., Matsumura, F. Toxicity of metabolites of dieldrin, photodieldrin, and endrin in the cockroach. Arch. Environ. Contam. Toxicol. 11, 635–643 (1982). https://doi.org/10.1007/BF01056373

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  • DOI: https://doi.org/10.1007/BF01056373

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