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Co-solvent modulation of the inclusion selectivity ofβ-cyclodextrin

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Abstract

The solubility ofβ-CD, which is increased to 87 gL−1 in 75% water - 25% isopropanol mixtures, does not behave in a linear fashion as a function of the water/isopropanol ratio. Application of this increased solubility to the formation of inclusion complexes betweenβ-cyclodextrin and cineole : eugenol, cineole : pinene and eugenol : pinene shows strong solvent modulation of the inclusion selectivity. The proportion of guests complexed is in inverse ratio to the compatibility of the guests in the solvent mixture.

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Authors and Affiliations

  1. UPR 180, CNRS, Laboratoire de Physique, Centre Pharmaceutique, Université de Paris-Sud, 92290, Châtenay Malabry, France

    C. Donzé, A. Chatjigakis & A. W. Coleman

Authors
  1. C. Donzé
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  2. A. Chatjigakis
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  3. A. W. Coleman
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Donzé, C., Chatjigakis, A. & Coleman, A.W. Co-solvent modulation of the inclusion selectivity ofβ-cyclodextrin. J Incl Phenom Macrocycl Chem 13, 155–161 (1992). https://doi.org/10.1007/BF01053639

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  • DOI: https://doi.org/10.1007/BF01053639

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