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6-Hydroxyalkylamino-6-deoxy-cyclodextrins: Towards dendrimeric host-molecules

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Abstract

6-Perhydroxyalkylamino-6-perdeoxy-β-cyclodextrins have been synthesised by treating 6-perbromo-6-perdeoxy-cyclodextrins with hydroxyalkylamines. The products (1, 2) are precursors of dendrimeric cyclodextrins in which the cavity provides access for the guest to interact with the branches. A fluorescence study has demonstrated the effects of the branches on binding of anilinonaphthalene sulfonate probes. The hosts show selectivity towards guests, and pH-dependence of binding, consistent with polar interaction between guest sulfonate anions and the protonated amino groups of the dendrimeric structure.

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Authors and Affiliations

  1. National University of Ireland, Ireland

    C. Ahern, R. Darcy, F. O'Keeffe & P. Schwinté

  2. Laboratory for Carbohydrate and Molecular Recognition Chemistry, Department of Chemistry, University College Dublin, 4, Dublin, Ireland

    R. Darcy, F. O'Keeffe & P. Schwinté

Authors
  1. C. Ahern
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  2. R. Darcy
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  3. F. O'Keeffe
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  4. P. Schwinté
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Ahern, C., Darcy, R., O'Keeffe, F. et al. 6-Hydroxyalkylamino-6-deoxy-cyclodextrins: Towards dendrimeric host-molecules. J Incl Phenom Macrocycl Chem 25, 43–46 (1996). https://doi.org/10.1007/BF01041533

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  • DOI: https://doi.org/10.1007/BF01041533

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