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Effects of polar additives on the enzyme enantioselectivity of an esterification reaction in organic solvents

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Summary

The enantioselectivity ofcandida cylindracea lipase in esterification between ibuprofen and 1-butanol in organic solvents is influenced by adding a small amount of polar solvents. The results show that both the solvents and the amount added affected the reaction. Addition of 0.05% (v/v) N,N-dimethylformamide increase the ee value of the ester from 57.5% of no addition to that of 91%.

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Authors and Affiliations

  1. Institute of Chemical Metallurgy, Academia Sinica, P.O.Box 353, Beijing, P.R. China

    G. Duan & J. Y. Chen

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  1. G. Duan
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  2. J. Y. Chen
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Duan, G., Chen, J.Y. Effects of polar additives on the enzyme enantioselectivity of an esterification reaction in organic solvents. Biotechnol Lett 16, 1065–1068 (1994). https://doi.org/10.1007/BF01022404

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  • DOI: https://doi.org/10.1007/BF01022404

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