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Lymphocyte-reactive antibodies in acquired immune deficiency syndrome

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Abstract

Antilymphocyte antibodies were studied using the Terasaki microcytotoxicity technique in 21 gay patients including 7 with Kaposi's sarcoma, 5 with opportunistic infection, and 9 with lymphadenopathy syndrome. A significant increase in lymphocyte-reactive antibody was noted in 61% of this group. Similar studies using serum from 25 apparently healthy gay males showed lymphocytotoxic antibody in only one instance. When isolated T-cell subsets (OKT4+ or OKT8+) were utilized, a few sera from acquired immune deficiency syndrome (AIDS) patients apparently showed preferential killing for helper-inducer or suppressor-cytotoxic T-cell subsets, however, this showed no correlation with T-cell phenotypic profiles of OKT4 or OKT8+ cells in concurrent peripheral blood studies. When isolated normal OKT4 or OKT8 T-cell subsets were treated with complement and AIDS serum showing apparent T-cell subset specificity and treated T cells added to B cells, macrophages, and OKT4 or OKT8 cells cultured with pokeweed mitogen, no discernible effect on either help or suppression of IgG or IgM synthesis was recorded.

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References

  1. Gottlieb MS, Schroff R, Schanker HM,et al. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: Evidence of a new acquired cellular immunodeficiency. N Engl J Med 305:1425–1431, 1981

    Google Scholar 

  2. Masur H, Michelis MA, Greene JB,et al. An outbreak of community-acquired Pneumocystis carinii pneumonia: Initial manifestation of cellular immune dysfunction. N Engl J Med 305:1431–1438, 1981

    Google Scholar 

  3. Siegel FP, Lopez C, Hammer GS,et al. Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med 305:1439–1444, 1981

    Google Scholar 

  4. Update on Kaposi's sarcoma and opportunistic infections in previously healthy persons—United States. Morbid Mortal Week Rep 31:294, 300–301, 1982

    Google Scholar 

  5. Friedman-Kien AE, Laubenstein LJ, Rubinstein P,et al. Disseminated Kaposi's sarcoma in homosexual men. Ann Intern Med 96:693–700, 1982

    Google Scholar 

  6. Mildvan D, Mathur U, Enlow RW,et al. Opportunistic infections and immune deficiency in homosexual men. Ann Intern Med 96:700–704, 1982

    Google Scholar 

  7. Hensley GT, Moskowitz LB, Pitchenik AE,et al. Opportunistic infections and Kaposi's sarcoma among Haitians in the United States. Morbid Mortal Week Rep 31:353–354, 360–361, 1982

    Google Scholar 

  8. Vicira J, Frank E, Spira TJ, Landesman SH: Acquired immune deficiency in Haitians opportunistic infections in previously healthy Haitian immigrants. N Engl J Med 308:125–129, 1983

    Google Scholar 

  9. Pitchenik AE, Fischl MA, Dickinson GM, Becker DM, Fournier AM, O'Connell MT, Colton RM, Spira TJ: Opportunistic infections and Kaposi's sarcoma among Haitians: evidence of a new acquired immunodeficiency state. Ann Intern Med 98:277–283, 1983

    Google Scholar 

  10. Davis KC, Horsburgh CR, Hasiba U, Schocket AL, Kirkpatrick CH: Acquired immunodeficiency syndrome in a patient with hemophilia. Ann Intern Med 98:284–286, 1983

    Google Scholar 

  11. Center for Disease Control: Update on acquired immune deficiency syndrome (AIDS)—United States. Morbid Mortal Week Rep 31:507–508, 513–514, 1982

    Google Scholar 

  12. Poon MC, Landay A, Prasthofer EF, Stagno S: Acquired immunodeficiency syndrome with pneumocystis carinii pneumonia andMycobacterium avium-intracellulare infection in a previously healthy patient with classic hemophilia. Clinical, immunologic and virologic findings. Ann Intern Med 98:287–290, 1983

    Google Scholar 

  13. Elliott JL, Hoppes WL, Platt MS, Thomas JG, Patel ID, Gansar A: The acquired immunodeficiency syndrome andMycobacterium avium-intracellulare bacteremia in a patient with hemophilia. Ann Intern Med 98:290–293, 1983

    Google Scholar 

  14. Mottironi VD, Terasaki PI: Lymphocytotoxins in disease.In Histocompatability Testing. Baltimore, Williams and Wilkins, 1970, p 301

    Google Scholar 

  15. Dawkins RL, Witt C, Richmond J, Sagenschneider K, Zilko PJ: Lymphocytotoxic antibodies in disease. Austral NZ J Med (Suppl 1) 8:81–86, 1978

    Google Scholar 

  16. Terasaki PI, Mottironi VD, Barnett EV: Cytotoxins in disease, autocytotoxins in lupus. N Engl J Med 283:724–728

  17. Searles RP, Williams RC Jr: Lymphocyte-reactive antibodies in SLE. Clinics. Rheum Dis 8:77–90, 1982

    Google Scholar 

  18. Morimoto C, Reinherz JL, Abe T, Hommer M, Schlossman SF: Characteristics of anti-T cell antibodies in systemic lupus erythematosus: Evidence for selective reactivity with normal suppressor cells defined by monoclonal antibodies. Clin Immunol Immunopathol 16:474–484, 1980

    Google Scholar 

  19. Morimoto C, Reinherz EL, Schlossman SF, Schur PH, Mills JA, Steinberg AD: Alterations in immunoregulatory T cell subsets in active systemic lupus erythematosus. J Clin Invest 66:1171–1174, 1980

    Google Scholar 

  20. Bresnihan B, Jasin HE: Suppressor function of peripheral blood mononuclear cells in normal individuals and patients with systemic lupus erythematosus. J. Clin Invest 59:106–116, 1977

    Google Scholar 

  21. Sagawa A, Abdou NI: Suppressor-cell dysfunction in systemic lupus erythematosus. J Clin Invest 62:789–796, 1978

    Google Scholar 

  22. Center for Disease Control: Update on acquired immune deficiency syndrome (AIDS)—United States. Morbid Mortal Week Rep 31:507–514, 1982

    Google Scholar 

  23. Terasaki PI, McClelland JD: Microdroplet assay of human serum cytotoxins. Nature 204:998–1000, 1964

    Google Scholar 

  24. Williams RC Jr, Froelich CJ, Kilpatrick K, Crowe WE, Levinson JE: T cell subset specificity of lymphocyte reactive factors in juvenile rheumatoid arthritis and systemic lupus erythematosus sera. Arthr Rheum 24:585–591, 1981

    Google Scholar 

  25. Bankhurst AD, Williams RC Jr: Identification of DNA-binding lymphocytes in patients with systemic lupus erythematosus. J Clin Invest 56:1378–1385, 1975

    Google Scholar 

  26. Rodriguez MA, Prinz WA, Sibbitt WL, Bankhurst AD, Williams RC Jr: Alpha interferon increases immunoglobulin production in cultured human mononuclear leukocytes. J Immunol 130:1215–1219, 1983

    Google Scholar 

  27. Cunningham-Rundles S, Michelis MA, Masur H: Serum suppression of lymphocyte activation in vitro in acquired immunodeficiency disease. J Clin Immunol 3:156–165, 1983

    Google Scholar 

  28. Williams RC Jr, Lies RB, Messner RP: Inhibition of mixed leukocyte culture responses by serum and γ-globulin fractions from certain patients with connective tissue disorders. Arthr Rheum 16:597–605, 1973

    Google Scholar 

  29. Wernet P, Kunkel HG: Antibodies to a specific surface antigen of T cells in human sera inhibiting mixed leukocyte culture reactions. J Exp Med 138:1021–1026, 1973

    Google Scholar 

  30. Okudaira K, Searles RP, Ceuppens JL, Goodwin JS, Williams RC Jr: Anti-Ia reactivity in sera from patients with systemic lupus erythematosus. J Clin Invest 69:17–24, 1982

    Google Scholar 

  31. Okudaira K, Searles RP, Goodwin JS, and Williams RC Jr: Antibodies in the sera of patients with systemic lupus erythematosus which block the binding of monoclonal anti-Ia to positive targets also inhibit the autologous mixed lymphocyte response. J Immunol 129:582–586, 1982

    Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Bernalillo County Medical Center, University of New Mexico, 87131, Albuquerque, New Mexico

    Ralph C. Williams Jr., Henry Masur & Thomas J. Spira

  2. Critical Care Medicine Laboratory, National Institutes of Health, 20205, Bethesda, Maryland

    Ralph C. Williams Jr., Henry Masur & Thomas J. Spira

  3. Division of Immunology, Communicable Disease Center, Centers for Disease Control, 30333, Atlanta, Georgia

    Ralph C. Williams Jr., Henry Masur & Thomas J. Spira

Authors
  1. Ralph C. Williams Jr.
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  2. Henry Masur
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  3. Thomas J. Spira
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Williams, R.C., Masur, H. & Spira, T.J. Lymphocyte-reactive antibodies in acquired immune deficiency syndrome. J Clin Immunol 4, 118–123 (1984). https://doi.org/10.1007/BF00915045

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