Conclusions
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1.
Diethyl chlorophosphite “phosphorylates” the hydroxy group in serine, carbobenoxyserine and the p-nitrobenzyl ester of serine, and also in Gly-Ser and Ala-Ser. The reaction does not go to completion at room temperature, and instead a certain equilibrium is set up.
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2.
Diethyl chlorophosphite at room temperature does not acylate the N-terminal group of the amino acid or peptide.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 5, pp. 927–928, May. 1966.
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Shibnev, V.A., Poroshin, K.T. & Khalikov, S.K. Use of diethyl chlorophosphite to acylate the hydroxy group of serine in peptides. Russ Chem Bull 15, 886–887 (1966). https://doi.org/10.1007/BF00849395
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DOI: https://doi.org/10.1007/BF00849395