Summary
The mutantscut 6 (ct6) andBeadex of Jollos (Bx J) show nicks in the wing margins as well as other malformations in different regions of the body. Clonal analysis of the wing disk's development in these mutants indicates that massive cell loss occurs during the third larval instar. Morphogenetic mosaics, originating from mitotic recombination, reveal a non-autonomous behaviour of both mutant and wild-type cells. X-rays applied during the third larval instar produce phenocopies of these mutants. A clonal and a genetic analysis of these phenocopies has been carried out.
The hypothesis that scalloping mutants such asct 6, BxJ and others, as well as X-rays, affect properties of cellular interaction, such as cell adhesivity or cohesion, is discussed. Morphogenetic mosaics in the wing margin suggest that the differentiation of the marginal cuticular elements requires the interaction of the cells of the ventral and dorsal surfaces of the wing.
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References
Auerbach, C.: The development of the legs, wings and halteres in wildtype and some mutant strains ofDrosophila melanogaster. Trans. Roy. Soc. Edinburgh58, 787–815 (1936)
Becker, H. J.: Über Röntgenmosaikflecken und Defektmutationen am Auge vonDrosophila und die Entwicklungsphysiologie des Auges. Z. Vererbungslehre88, 333–378 (1957)
Dobzhansky, T.: The influence of the quantity and quality of the chromosomal material on the size of the cells ofDrosophila melanogaster. Wilhelm Roux Archiv115, 363–379 (1929)
Friesen, H.: Rontgenmorphosen beiDrosophila. Wilhelm Roux Archiv134, 147–165 (1936)
Fristrom, D.: Cellular degeneration in the production of some mutant phenotypes inDrosophila melanogaster. Molec. Gen. Genetics103, 363–379 (1969)
Garcia-Bellido, A., Merriam, J. R.: Parameters of the wing imaginal disc development ofDrosophila melanogaster. Develop. Biol.24, 61–87 (1971)
Garcia-Bellido, A., Ripoll, P., Morata, G.: Developmental compartmentalization of the wing disk ofDrosophila. Nature, New Biology.245, 251–253 (1973)
Goldschmidt, R. B.: Experimentelle Mutation und das Problem der sogenannten Parallelinduktion. Biol. Zbl.49, 437–448 (1929)
Goldschmidt, R. B.: Gen und Außeneigenschaft (Untersuchungen anDrosophila). I. Z. Vererbl.69, 38–69 (1935a)
Goldschmidt, R. B.: Gen und Außeneigenschaft (Untersuchungen anDrosophila). III. Biol. Zbl.55, 535–554 (1935b)
Green, M. M.: The Beadex locus inDrosophila melanogaster on the nature of the mutantsBx 7 andBx 1. Genetics38, 91–105 (1953)
Henke, K., Finck, E., Ma, S. Y.: Über sensible Perioden für die Auslösung von Hitzemodifikationen beiDrosophila und die Beziehung zwischen Modifikationen und Mutationen. Z. Vererbsl.79, 267–316 (1941)
Lindsley, D. L., Grell, E. H.: Genetic variations ofDrosophila melanogaster. Carnegie Inst. Washington Publ.627 (1968)
Morata, G., Garcia-Bellido, A.: Behaviour in aggregates of irradiated imaginal disc cells ofDrosophila melanogaster. Wilhelm Roux Archiv172, 187–195 (1973)
Poodry, C. A., Schneiderman, H. A.: The ultrastructure of the developing leg ofDrosophila melanogaster. Wilhelm Roux Archiv166, 1–44 (1970)
Rizki, T. M., Rizki, R. M.: B.U.D.R. induced somatic mutations inDrosophila. Abstract of Genetics60, 215 (1968)
Schweizer, P.: Wirkung von Röntgenstrahlen auf die Entwicklung der männlichen Genitalprimordien vonDrosophila melanogaster und Untersuchung von Erholungsvorgängen durch Zellklon-Analyse. Biophysik8, 158–188 (1972)
Spreij, T. E.: Cell death during the development of the imaginal disks ofCalliphora erythrocephala. Netherl. J. Zoology21, 221–264 (1971)
Waddington, C. H.: The genetic control of wing development inDrosophila. J. Genetics.41, 75–139 (1940)
Waddington, C. H.: Some developmental effects of X-rays inDrosophila. J. Exptl. Biol.19, 101–117 (1942)
Wehman, H. J.: Fine structure ofDrosophila wing imaginal discs during early stages of metamorphosis. Wilhelm Roux Archiv163, 375–390 (1969)
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Santamaria, P., Garcia-Bellido, A. Developmental analysis of two wing scalloping mutantsct 6 andBx J ofDrosophila melanogaster . Wilhelm Roux' Archiv 178, 233–245 (1975). https://doi.org/10.1007/BF00848431
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DOI: https://doi.org/10.1007/BF00848431