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Adhesion molecules in rheumatoid arthritis

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References

  1. Lipsky PE (1997) Rheumatoid arthritis. In: Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL (eds) Harrison's principles of internal medicine, 14th edn. McGraw Hill, New York, p 1880

    Google Scholar 

  2. Harris ED (ed) (1997) Reumatoid arthritis. Saunders, Philadelphia

    Google Scholar 

  3. Van Boxel JA, Paget SA (1975) Predominantly T cell infiltrate in rheumatoid synovial membranes. N Engl J Med 293: 517

    Google Scholar 

  4. Janossy G, Panay GS, Duke O, Bofill M, Poulter LW, Goldstein G (1981) Rheumatoid arthritis: a disease of T lymphocyte/macrophage immunoregulation. Lancet IT: 839

    Google Scholar 

  5. Kurosaka M, Ziff M (1983) Immunoelectron microscopic study of the distribution of T cell subsets in rheumatoid synovium. J Exp Med 158: 1191

    Google Scholar 

  6. Cush IT, Lipsky PE (1988) Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum 31:1230

    Google Scholar 

  7. Stastny P (1978) Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med 298:869

    Google Scholar 

  8. Lipsky PE, Davis LS, Cush JJ, Oppenheimer-Marks N (1989) The role of cytokines in the pathogenesis of rheumatoid arthritis. Springer Semin Immunopathol 11: 123

    Google Scholar 

  9. Feldmann M, Brennan FM, Maini RN (1996) Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14:397

    Google Scholar 

  10. Koch AE, Kunkel SL, Strieter RM (1995) Cytokines in rheumatoid arthritis. J Invest Med 43: 28

    Google Scholar 

  11. Firestein GS, Xu WD, Townsend K, Broide D, Alvaro-Gracia J, Glasebrook A, Zvaifler NJ (1988) Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (IL-2 and IL-3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis. J Exp Med 168:1573

    Google Scholar 

  12. Firestein GS, Alvaro-Garcia JM, Maki R (1990) Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol 144:3347

    Google Scholar 

  13. Simon AK, Seipelt E, Sieper J (1994) Divergent T -cell cytokine patterns in inflammatory arthritis. Proc Natl Acad Sci USA 91: 8562

    Google Scholar 

  14. Brennan FM, Field M, Chu CQ, Feldmann M, Maim RN (1991) Cytokine expression in rheumatoid arthritis. Br J Rheumatol 30 [Suppl 1]: 76–80

    Google Scholar 

  15. Dolhain RJEM, Heiden AN van der, Haar NT ter, Breedveld FC, Miltenburg AMM (1997) Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis. Arthritis Rheum 39: 1961

    Google Scholar 

  16. Isomäki P, Luukkainen R, Toivanen P, Punnonen J (1996) The presence of interleukin-13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis. Arthritis Rheum 39:1693

    Google Scholar 

  17. Kotake S, Schumacher HR Jr, Yarboro CH, Arayssi TK, Pando JA, Kanik KS, Gourley MF, Klippel JH, Wilder RL (1997) In vivo gene expression of type 1 and type 2 cytokines in synovial tissues from patients with early stages of rheumatoid, reactive, and undifferentiated arthritis. Proc Assoc Am Phy 109:286

    Google Scholar 

  18. Bucht A, Larsson P, Weisbrot L, Thorne C, Pisa P, Smedegard G, Keystone EC, Grönberg A (1996) Expression of interferon-gamma (IFN-γ), IL-10, IL-12 and transforming growth factor-beta (TGF-β) mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid arthritis (RA). Clin Exp Immunol 103: 357

    Google Scholar 

  19. Wagner AD, Bjornsson J, Bartley GB, Goronzy JJ, Weyand CM (1996) Interferon gamma producing T cells in giant cell vasculitis represent a minority of tissue infiltrating cells and are located distant from the site of pathology. Am J Pathol 148: 1925

    Google Scholar 

  20. Maurice MM, Nakamura J, Voort EAM van der, Vliet AI van, Staal FIT, Tak PP, Breedveld FC, Verweij CL (1997) Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis. J Immunol 158: 1458

    Google Scholar 

  21. Maurice MM, Lankester AC, Bezemer AC, Geertsma ME, Tak PP, Breedveld FC, Lier RAW van, Verweij CL (1997) Defective TCR-medicated signaling in synovial T cells in rheumatoid arthritis. J Immunol 159:2973

    Google Scholar 

  22. Thomas R, McIlraith M, Davis L, Lipsky PE (1992) Rheumatoid synovium is enriched in CD45RW'm memory T cells that are potent helpers for B cell differentiation. Arthritis Rheum 35: 1455

    Google Scholar 

  23. Cush JJ, Lipsky PE (1988) Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum 31: 1230

    Google Scholar 

  24. Kohem CL, Brezinschek RI, Wisbey H, Tortorella C, Lipsky PE, Oppenheimer-Marks N (1996) Enrichment of differentiated CD45RBdim, CD27-memory T cells in the peripheral blood, synovial fluid, and synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 39: 844

    Google Scholar 

  25. Hemler ME, Glass D, Coblyn JS, Jacobson JG (1986) Very late activation antigens on rheumatoid synovial T lymphocytes. Association with stages of T cell activation. J Clin Invest 78: 696

    Google Scholar 

  26. Takahashi H, Söderström K, Nilsson E, Kiessling R, Patarroyo M (1992) Integrins and other adhesion molecules on lymphocytes from synovial fluid and peripheral blood of rheumatoid arthritis patients. Eur J Immunol 22:2879

    Google Scholar 

  27. Afeltra A, Galeazzi M, Ferri GM, Amoroso A, De Pita O, Porzio F, Bonomo L (1993) Expression of CD69 antigen on synovial fluid T cells in patients with thrumatoid arthritis and chronic synovitis. Ann Rheum Dis 52:457

    Google Scholar 

  28. Laffon A, Garcia Vicuna R, Humbria A, Postigo AA, Corbi AL, Landazuri MO de, Sanchez Madrid F (1991) Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis. J Clin Invest 88: 546

    Google Scholar 

  29. Sfikakis PP, Zografou A, Viglis V, Iniotaki-Theodoraki A, Piskontaki I, Tsokos GC, Sfikakis P, Choremi-Papadopoulou H (1995) CD28 expression on T cell subsets in vivo and CD28-mediated T cell response in vitro in patients with rheumatoid arthritis. Arthritis Rheum 38: 649

    Google Scholar 

  30. Kelleher D, Murphy A, Hall Nicola, Omary MB, Kearns G, Long A, Casey EB (1995) Expression of CD44 on rheumatoid synovial fluid lymphocytes. Ann Rheum Dis 54: 566

    Google Scholar 

  31. Yokota A, Murata N, Saiki O, Shimizu M, Springer TA, Kishimoto T (1995) High avidity state of leukocyte function-associated antigen-1 on rheumatoid synovial fluid T lymphocytes. J Immunol 155: 4118

    Google Scholar 

  32. Isomäki P, Aversa G, Cocks BG, Luukkainen R, Saario R, Toivanen P, Vries JE de, Punnonen J (1997) Increased expression of signaling lymphocytic activation molecule in patients with rheumatoid arthritis and its role in the regulation of cytokine production in rheumatoid synovium. J Immunol 159: 2986

    Google Scholar 

  33. MacDonald KPA, Nishioka Y, Lipsky PE, Thomas R (1997) Functional CD40 ligand is expressed by T cells in rheumatoid arthritis. J Clin Invest 100: 2404

    Google Scholar 

  34. Tortorella C, Schulze-Koops H, Thomas R, Splawski JB, Davis LS, Picker LJ, Lipsky PE (1995) Expression of CD45RB and CD27 identifies subsets of CD4+ memory T cells with different capacities to induce B cell differentiation. J Immunol 155: 149

    Google Scholar 

  35. Schulze-Koops H, Lipsky PE, Kavanaugh AF, Davis LS (1995) Elevated Thl or Th0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis. Modulation by treatment with anti-ICAM-1 correlates with clinical benefit. J Immunol 155:5029

    Google Scholar 

  36. Brezinschek RI, Lipsky PE, Galea P, Vita R, Oppenheimer-Marks N (1995) Phenotypic characterization of CD4+ T cells that exhibit a transendothelial migratory capacity. J Immunol 154:3062

    Google Scholar 

  37. Jalkanen S, Steere AC, Fox RI, Butcher EC (1986) A distinct endothelial cell recognition system that controls lymphocyte traffic into inflamed synovium. Science 233: 556

    Google Scholar 

  38. Oppenheimer-Marks N, Ziff M (1986) Binding of normal human mononuclear cells to blood vessels in rheumatoid arthritis synovial membrane. Arthritis Rheum 29:789

    Google Scholar 

  39. Kavanaugh AF, Oppenheimer-Marks N (1992) The role of the endothelium in the pathogenesis of vasculitis. In: LeRoy EC (ed) Systemic vasculitis: the biological basis. Marcel Dekker, New York, pp 2748

    Google Scholar 

  40. Freemont AJ (1987) Molecules controlling lymphocyte-endothelial interactions in lymph nodes are produced in vessels in inflamed synovium. Ann Rheum Dis 4:924

    Google Scholar 

  41. Freemont AJ, Jones CJP, Bromley M, Andrews P (1983) Changes in vascular endothelium related to lymphocyte collections in diseased synovia. Arthritis Rheum 26:1427

    Google Scholar 

  42. Iguchi T, Ziff M (1986) Electron microscopic study of rheumatoid synovial vasculature. J Clin Invest 77:355

    Google Scholar 

  43. Yanni G, Whelan A, Feighery C, Fitzgerald O, Bresnihan B (1993) Morphometric analysis of synovial membrane blood vessels in rheumatoid arthritis: associations with the immunohistologic features, synovial fluid, cytokine levels and the clinical course. J Rheumatol 20:634

    Google Scholar 

  44. Picker LJ, Siegelman MH (1993) Lymphoid tissues and organs. In: Paul WE (ed) Fundamental immunology, 3rd edn. Raven Press, New York, pp 145–197

    Google Scholar 

  45. Ziff M, Iguchi T (1987) Electron microscopic study of rheumatoid synovial vasculature: intimate relationship between tall endothelium and lymphoid aggregation. Int J Tissue React 9:273

    Google Scholar 

  46. Munro JM, Pober JS, Cotran RS (1989) Tumor necrosis factor and interferon- induce distinct patterns of endothelial activation and associated leukocyte accumulation in skin ofPapio anubis. Am J Pathol 135:121

    Google Scholar 

  47. Fossum S, Smith ME, Ford WL (1983) The recirculation of T and B lymphocytes in the athymic, nude rat. Scand J Immunol 17: 551

    Google Scholar 

  48. Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1: 27

    Google Scholar 

  49. Iruela-Arispe ML, Dvorak DF (1997). Angiogenesis: a dynamic balance of stimulators and inhibitors. Thromb Haemost 78: 672

    Google Scholar 

  50. Polverini PJ (1995) The pathophysiology of angiogeneis. Crit Rev Oral Biol Med 6: 230

    Google Scholar 

  51. Ware JA, Simons M (1997). Angiogenesis in ischemic heart. Nat Med 3:158

    Google Scholar 

  52. Norrby K (1997) Angiogenesis: new aspects relating to its inititation and control. APMIS 105: 417

    Google Scholar 

  53. Cao Y, Linden P, Shima D, Browne F, Folkman J (1996) In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor. J Clin Invest 98:2507

    Google Scholar 

  54. Rak J, Filums J, Finkenzeller G, Grugel S, Marmé D, Kerbel RS (1995) Oncogenes as inducers of tumor angiogenesis. Cancer Metastasis Rev 14: 263

    Google Scholar 

  55. Li J, Perrella MA, Tsai JC, Yet SF, Hsieh CM, Yoshizumi M, Patterson C, Endege WO, Zhou F, Lee ME (1995) Induction of vascular endothelial growth factor gene expression by interleukin-1 beta in rat aortic smooth muscle cells. J Biol Chem 270:308

    Google Scholar 

  56. Harada S, Nagy JA, Sullivan KA, Thomas KA, Endo N, Rodan GA, Rodan SB (1994) Induction of vascular endothelial growth factor expresison by prostaglandin E2 and El in osteoblasts. J Clin Invest 93:2490

    Google Scholar 

  57. Thomas K (1996) Vascular endothelial growth factor, a potent and selective angiogenic agent. J Biol Chem 271:603

    Google Scholar 

  58. Dvorak HF, Detmanr M, Claffey KP, Nagy JA, Water L van der, Senger DR (1995) Vascular permeability factor/ vascular endothelial growth factor: an important mediator of angiogenesis in malignancy and inflammation. Int Arch Allergy Immunol 107: 233

    Google Scholar 

  59. Quinn TP, Peters KG, De Vries C, Ferrara N, Williams LT (1993) Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci USA 90:7533

    Google Scholar 

  60. Vries C de, Escobedo JA, Ueno JA, Houck K, Ferrara N, Williams LT (1992) The furs-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255: 989

    Google Scholar 

  61. Ferrara N, Henzel WJ (1989) Pituitary follicular cells secrete a novel heparin-binding groath factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161:851

    Google Scholar 

  62. Ferrara N, Houck K, Jakeman L, Leung D (1992) Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocrinol Rev 13: 18

    Google Scholar 

  63. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380: 435

    Google Scholar 

  64. Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea KS, Powell-Braxton L, Hillan KJ, Moore MW (1996) Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380:439

    Google Scholar 

  65. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, Schuh AC (1995) Failure of blood-island formation and vasculogenesis in FLK-1 deficient mice. Nature 376: 62

    Google Scholar 

  66. Fong GH, Rossant J, Gertsenstein M, Breiitman ML (1995) Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376:66

    Google Scholar 

  67. Fava RA, Olsern NJ, Spencer-Green G, Yeo KT, Berse B, Jackman RW, Senger DR, Dvorak HF, Brown LF (1994) Vascular permeability factor/endothelial growth factor (VPFNEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med 180: 341

    Google Scholar 

  68. Nagashima M, Yoshino S, Ishiwata T, Asano G (1995) Role of vascular endothelial growth factor in angiogenesis of rheumatoid arthritis. J Rheumatol 22: 1624

    Google Scholar 

  69. Rusnati M, Presta M (1996) Interaction of angiogenic basic fibroblast growth factor with endothelial heparan sulfate protenglycans. Biological implications in neovascularization. Int J Clin Lab Res 26: 15

    Google Scholar 

  70. Risau W (1996) What, if anything, is an angiogenic factor? Cancer Metastasis Rev 15: 149

    Google Scholar 

  71. Maione TE, Gray GS, Petro J, Hunt AJ, Dormer AL, Bauer SI, Carson HF, Sharpe RJ (1990) Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. Science 247: 77

    Google Scholar 

  72. Maione TE, Gray GS, Hunt AJ, Sharpe RJ (1991) Inhibition of tumor growth in mice by an analogue of platelet factor 4 that lacks affinity for heparin and retains potent angiostatic activity. Cancer Res 51:2077

    Google Scholar 

  73. Dameron KM, Volpert OV, Tainsky M, Bouck N (1994) Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 265: 1582

    Google Scholar 

  74. O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH, Folkman J (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79: 315

    Google Scholar 

  75. O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasins G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J (1997) Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88: 277

    Google Scholar 

  76. DiPietro LA (1997) Thrombospondin as a regulator of angiogenesis. EXS 79: 295

    Google Scholar 

  77. Lawler J, Duquette M, Whittaker CA, Adams JC, McHenry K, De Simone DW (1993) Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family. J Cell Biol 120:1059

    Google Scholar 

  78. Bornstein P (1992) The thrombospondins: structure and regulation of expression. FASEB J 6: 3290

    Google Scholar 

  79. Bagavandoss P, Wilks JW (1990) Specific inhibition of endothelial cell proliferation by thrombospondin. Biochem Biophys Res Commun 170: 867

    Google Scholar 

  80. Canfield AE, Boot-Handford RP, Schor AM (1990) Thrombospondin gene expression by endothelial cells in culture is modulated by cell proliferation, cell shape and the substratum. Biochem J 268:225

    Google Scholar 

  81. Lawler J, Weinstein R, Hynes RO (1988) Cell attachment to thrombospondin: the role of ARG-GLY ASP, calcium, and integrin receptors. J Cell Biol 107:2351

    Google Scholar 

  82. Murphy-Ullrich JE, Höök M (1989) Thrombospondin modulates focal adhesions in endothelial cells. J Cell Biol 109:1309

    Google Scholar 

  83. Leung LLK, Li WX, McGregor JL, Albrecht G, Howard RJ (1992) CD36 peptides enhance or inhibit CD36-thrombospondin binding. J Biol Chem 267:18244

    Google Scholar 

  84. O'Shea KS, Dixit VM (1988) Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo. J Cell Biol 107:2737

    Google Scholar 

  85. Koch A, Friedman J, Burrows JC, Haines GK, Bouck NP (1993) Localization of the angiogenesis inhibitor thrombospondin in human synovial tissues. Pathobiology61: 1–6

    Google Scholar 

  86. Endresen GK (1989) Evidence for the activation of platelets in the synovial fluid from patients with rheumatoid arthritis. Rheumatol Int 9: 19

    Google Scholar 

  87. Koch AE, Halloran MM, Haskell CJ, Shah MR, Polverini PJ (1995) Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature 376:517

    Google Scholar 

  88. Friedlander M, Brooks PC, Shaffer RW, Kincaid CM, Varner JA, Cheresh DA (1995) Definition of two angiogenic pathways by distinct av integrins. Science 270: 1500

    Google Scholar 

  89. Varner JA, Brooks PC, Cheresh DA (1995) The integrin avf angiogenesis or apoptosis. Cell Adhes Commun 3: 367

    Google Scholar 

  90. Polverini PJ (1996) Cellular adhesion molecules. Newly identified mediators of angiogenesis. Am J Pathol 148: 1023

    Google Scholar 

  91. Woessner JF Jr (1991) Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB 15: 2145

    Google Scholar 

  92. Oliver SJ, Banquerigo ML, Brahn E (1994) Suppression of collagen-induced arthritis using inhibitor, AGM-1470, and a micrombule stabilizer, Taxol. Cell Immunol 157:291

    Google Scholar 

  93. Rendt KE, Barry TS, Jones DM, Richter CB, McCachren SS, Haynes BF (1993) Engraftment of human synovium into severe combined immune deficient mice. J Immunol 151:7324

    Google Scholar 

  94. Sack U, Kuhn H, Ermann J, Kinne RW, Vogt S, Jungmichl D, Emmrich F (1993) Synovial tissue implants from patients with rheumatoid arthritis cause cartilage destruction in knee joints of SCID.bg mice. J Rheumatol 19: 10

    Google Scholar 

  95. Geiler T, Kriegsmann J, Keyszer GM, Gay RE, Gay S (1994) A new model for rheumatoid synovial tissue and normal human cartilage into SCID mice. Arthritis Rheum 37:1664

    Google Scholar 

  96. Jorgensen C, Couret I; Hellier I, Bologna C, Canovas F, Brochier J, Reme T, Sany J (1996) In vivo migration of radiolabeled lymphocytes in rheumatoid synovial tissue engrafted in SCID mice: implication of β2 and β7-integrin. J Rheumatol 23:32

    Google Scholar 

  97. Muller-Ladner U, Kriegsmann J, Franklin BN, Matsumoto S, Geiler T, Gay RE, Gay S (1996) Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol 140:1607

    Google Scholar 

  98. Mima T, Saeki Y, Ohshima S, Nishimoto N, Matsushita M, Shimizu M, Kobayashi Y, Nomura T, Kishimoto T (1995) Transfer of rheumatoid arthritis into severe combined immunodeficient mice. The pathogenetic implications of T cell populations oligoclonally expanding in the rheumatoid joints. J Clin Invest 96: 1746

    Google Scholar 

  99. Brooks PC, Strömblad S, Klemke R, Visscher D, Sarkar FH, Cheresh DA (1995) Antiintegrin αvβ5 blocks human breast cancer growth and angiogenesis in human skin. J Clin Invest 96:1815

    Google Scholar 

  100. Christofidou-Solomidou M, Bridges M, Murphy GF, Albelda SM, DeLisser HM (1997) Expression and function of endothelial cell av integrin receptors in wound-induced human angiogenesis in human skin/SCID chimeras. Am J Pathol 151:975

    Google Scholar 

  101. Jorgensen C, Courets J, Canovas F, Bologna C, Brochier J, Reme T, Lipsky P, Sany J (1996) Mononuclear cell retention in rheumatoid synovial tissue engrafted in severe combined immunedeficient (SCID) mice is up-regulated by tumour necrosis factor-alpha (TNF-α) and mediated through intercellular adhesion molecule-1 (ICAM-1). Clin Exp Immunol 106: 20

    Google Scholar 

  102. Oppenheimer-Marks N, Lipsky PE (1994) Transendothelial migration of T cells in chronic inflammation. Immunologist 2:58

    Google Scholar 

  103. Hale LP, Martin ME, McCollum DE, Nunley JA, Springer TA, Singer KH, Haynes BF (1989) Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment. Arthritis Rheum 32:22

    Google Scholar 

  104. Koch A, Burrows JC, Haines GK, Carlos TM, Harlan JM, Leibovich SJ (1991) Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissue. Lab Invest 64: 313

    Google Scholar 

  105. Tak PP, Thurkow EW, Daha MR, Kluin PM, Smeets TJ, Meinders AE, Breedveld FC (1995) Expression of adhesion molecules in early rheumatoid synovial tissue. Clin Immunol Immunopathol 77:236

    Google Scholar 

  106. Grober IS, Bower BL, Ebling H, Athey B, Thompson CB, Fox DA, Stoolman LM (1993) Monocyte-endothelial adhesion in chronic rheumatoid arthritis. In situ detection of selectin and integrin dependent interactions. J Clin Invest 91: 2609

    Google Scholar 

  107. Yousseff PP, Triantafillou S, Parker A, Coleman M, Roberts-Thomson PJ, Ahern MJ, Smith MD (1997) Variability in cytokine and cell adhesion molecule staining in arthroscopic synovial biopsies: quantification using color video image analysis. J Rheumatol 24: 2291

    Google Scholar 

  108. Geiger B, Ayalon O (1992) Cadherins. Annu Rev Cell Biol 8: 307

    Google Scholar 

  109. Salmi M, Kalimo K, Jalkanen S (1993) Induction and function of vascular adhesion protein-1 at sites of inflammation. J Exp Med 178:2255

    Google Scholar 

  110. Salmi M, Jalkanen S (1996) Human vascular adhesion protein 1 (VAP-1) is a unique sialoglycoprotein that mediates carbohydrate-dependent binding of lymphocytes to endothelial cells. J Exp Med 183: 569

    Google Scholar 

  111. Friedlander M, Brooks PC, Schaffer RW, Kincaid CM, Vamer JA, Cheresh DA (1995) Definition of two angiogenic pathways by distinct aV integrins. Science 270:1500

    Google Scholar 

  112. Oppenheimer-Marks N, Lipsky PE (1997) Adhesion molecules and the regulation of the migration of lymphocytes. In: Hamann A (ed) Adhesion molecules and chemokines in lymphocyte trafficking. The Netherlands, Harwood, pp 55–88

  113. Dinther-Janssen AC van, Horst E, Koopman G, Newmann W, Scheper RJ, Meijer CJ, Pals ST (1991) The VLA-4/VCAM-1 pathway is involved in lymphocyte adhesion to endothelium in rheumatoid synovium. J Immunol 147:4207

    Google Scholar 

  114. Oppenheimer-Marks N, Davis LS, Lipsky PE (1990) Human T lymphocyte adhesion to endothelial cells and transendothelial migration. Alteration of receptor use relates to the activation status of both the T cell and the endothelial cell. J Immunol 145: 140

    Google Scholar 

  115. Springer TA (1990) Adhesion receptors of the immune system. Nature 346: 425

    Google Scholar 

  116. Tanaka Y, Albelda SM, Horgan KJ, Seventer GA van, Shimizu Y, Newman W, Hallam J, Newman PJ, Buck CA, Shaw S (1992) CD31 expressed on distinctive T cell subsets is a preferential amplifier of β1 integrin-mediated adhesion. J Exp Med 176:245

    Google Scholar 

  117. Oppenheimer-Marks N, Brezinschek RI, Mohamadzadeh M, Vita R, Lipsky PE (1998) Interleukin-15 is produced by endothelial cells and increases the transendothelial migration of T cells in vitro and in the SCDI mouse-human rheumatoid arthritis model in vivo. J Clin Invest (in press)

  118. Altmann DM, Hogg N, Trowsdale J, Wilkinson D (1989) Cotransfection of ICAM-1 and HLA-DR reconstitutes human antigen-presenting cell function in mouse L cells. Nature 338: 512

    Google Scholar 

  119. Davis LS, Oppenheimer-Marks N, Bednarczyk JL, McIntyre BW, Lipsky PE (1990) Fibronectin promotes proliferation of naive and memory T cells by signaling through both the VLA-4 and VLA-5 integrin molecules. J Immunol 145: 785

    Google Scholar 

  120. Shimizu Y, Seventer GA van, Horgan KJ, Shaw S (1990) Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin. J Immunol 145:59

    Google Scholar 

  121. Seventer GA van, Shimizu Y, Horgan KJ, Shaw S (1990) The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells. J Immunol 144: 4579

    Google Scholar 

  122. Seventer GA van, Newman W, Shimizu Y, Nutman TB, Tanaka Y, Horgan KJ, Gopal TV, Ennis E, O'Sullivan D, Grey H, Shaw S (1991) Analysis of T cell stimulation by superantigen plus major histocompatability complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1. J Exp Med 174: 901

    Google Scholar 

  123. Damle NK, Klussman K, Leytze G, Ochs HD, Aruffo A, Linsley PS, Ledbetter JA (1993) Costimulation via vascular cell adhesion molecule-1 induces in T cells increased responsiveness to the CD28 counter-receptor B7. Cell Immunol 148:144

    Google Scholar 

  124. Kavanaugh AF, Davis LS, Nichols LA, Norris SH, Rothlein R, Scharschmidt LA, Lipsky PE (1992) Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule-1. Arthritis Rheum 37:992

    Google Scholar 

  125. Schulze-Koops H, Lipsky PE, Kavanaugh AF, Davis LS (1995) Elevated Thl- or Th0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis. Modulation by treatment with anti-ICAM-1 correlates with clinical benefit. J Immunol 155: 5029

    Google Scholar 

  126. Paleolog EM, Hunt M, Elliott MJ, Feldmann M, Maini RN, Woody IN (1996) Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritis. Arthritis Rheum 39: 1082

    Google Scholar 

  127. Lawrence MB, Springer, TA (1991) Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 65: 859

    Google Scholar 

  128. Butcher EC (1991) Leukocyte-endothelial cell recognition: three (or more) steps for specificity and diversity. Cell 67: 1033

    Google Scholar 

  129. Picker LJ, Warnock RA, Burns AR, Doerschuk CM, Berg EL, Butcher EC (1991) The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Cell 66:921

    Google Scholar 

  130. Kishimoto TK, Warnock RA, Jutila MA, Butcher EC, Lane C, Anderson DC, Smith CW (1991) Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/Dreg 56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro. Blood 78: 805

    Google Scholar 

  131. Huber AR, Kunkel SL, Todd RF III, Weiss SJ (1991) Regulation of transendothelial neutrophil migration by endogenous interleukin-8. Science 254: 99

    Google Scholar 

  132. Smith CW, Rothlein R, Hughes BJ, Mariscalco MM, Rudloff HE, Schmalsteig FC, Anderson DC (1988) Recognition of an endothelial determinant for C1318-dependent human neutrophil adherence and transendothelial migration. J Clin Invest 82:1746

    Google Scholar 

  133. Smith WC, Marlin SD, Rothlein R, Toman C, Anderson DC (1989) Cooperative interactions of LFA-I and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J Clin Invest 83: 2008

    Google Scholar 

  134. Muller WA, Weigel SA, Deng X, Phillips DM (1993) PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 178:449

    Google Scholar 

  135. Kansas GS, Spertini O, Stoolman LM, Tedder TF (1991) Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1. J Cell Biol 114: 351

    Google Scholar 

  136. Lasky, LA, Singer, MS, Yednock TA, Dowbenko D, Fennie C, Rodriguez H, Nguyen T, Stachel S, Rosen SD (1989) Cloning of a lymphocyte homing receptor reveals a lectin domain. Cell 56:1045

    Google Scholar 

  137. Masumoto A, Hemler ME (1993) Multiple activation states of VLA-4. Mechanistic differences between adhesion to CSI/fibronectin and to vascular cell adhesion molecule-1. J Biol Chem 268: 228

    Google Scholar 

  138. Alon R, Kassner PD, Carr MW, Finger EB, Hemler ME, Springer TA (1995) The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol 128: 1243

    Google Scholar 

  139. Lalor PF, Clements JM, Pigott R, Humphries MJ, Spragg JH, Nash GB (1997) Association between receptor density, cellular activation, and transformation of adhesive behavior of flowing lymphocytes binding to VCAM-1. Eur J Immunol 27:1442

    Google Scholar 

  140. Berg EL, Robinson MK, Wamock RA, Butcher EC (1991) The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor. J Cell Biol 114: 343

    Google Scholar 

  141. Kotovouri P, Tontti E, Pigott R, Shepard M, Kiso M, Hasegawa A, Renkonen R, Nortamo P; Altieri DC, Gahmberg CG (1993) The vascular E-selectin binds to the leukocyte integrins CD11/CD18. Glycobiology 3: 131

    Google Scholar 

  142. Sako D, Chang XJ, Barone KM, et al (1993) Expression cloning of a functional glycoprotein ligand for P-selectin. Cell 75:1179

    Google Scholar 

  143. Fuhlbrigge RC, Kieffer JD, Armerding D, Kopper TS (1997) Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 389:978

    Google Scholar 

  144. Galea P, Brezinschek R, Lipsky PE, Oppenheimer-Marks N (1994) Phenotypic characterizatin of CD4(−)/αβ TCR(+) and γδ TCR(+) T cells with a transendothelial migratory capacity. J Immunol 153:529

    Google Scholar 

  145. Baggiolini M, Dewald B, Moser B (1997) Human chemokines: an update. Annu Rev Immunol 15: 675

    Google Scholar 

  146. Kelner GS, Kennedy J, Bacon KB, et al (1994) Lymphotactin: a cytokine that represents a new class of chemokine. Science 266: 1395

    Google Scholar 

  147. Timothy N, Wells C, Peitsch MC (1997) The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and Expressed Sequence Tag Databases (1997) J Leukoc Biol 61: 545

    Google Scholar 

  148. Baggiolini M, Dewald D, Moser B (1994) Interleukin-8 and related chemotactic cytokines: CXC and CC chemokines. Adv Immunol 55: 97

    Google Scholar 

  149. Benbaruch A, Michiel DF, Oppenheim JJ (1995) Signals and receptors involved in recruitment of inflammatory cells. J Biol Chem 270:11703

    Google Scholar 

  150. Brennan FM, Zachariae COC, Chantry D, Larsen CG, Turner M, Maini RN, Matsushima K, Feldman M (1990) Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells. Eur J Immunol 20:2141

    Google Scholar 

  151. Schall TJ, Bacon K, Toy KJ, Goeddel DV (1990) Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 347:669

    Google Scholar 

  152. Lipes MA, Napolitano M, Jeang K-T, Chang NT, Leonard WJ (1988) Identification, cloning, and characterization of an immune activation gene. Proc Natl Acad Sci USA 85: 9704

    Google Scholar 

  153. Schall TJ, Bacon K, Camp RDR, Kaspari JW, Goeddel DV (1993) Human macrophage inflammatory protein-1α (MIP-1α) and MIP-1β chemokines attract distinct populations of lymphocytes. J Exp Med 177:1821

    Google Scholar 

  154. Rathanaswami P, Hachicha M, Sadick M, Schall TJ, McColl SR (1993) Expression of the cytokine RANTES in human rheumatoid synovial fibroblasts. J Biol Chem 268:5834

    Google Scholar 

  155. Streiter RM, Polverini PJ, Arenberg DA, Kunkel SL (1995) The role of CXC chemokines as regulators of angiogenesis. Shock 4: 155

    Google Scholar 

  156. Streiter RM, Polverini PJ, Kunkel SL (1995) The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J Biol Chem 270:27348

    Google Scholar 

  157. Ebnet K, Kaldijian EP, Anderson AO, Shaw S (1996) Orchestrated information transfer underlying leukocyte endothelial interactions. Annu Rev Immunol 14:155

    Google Scholar 

  158. Wilkinson PC, Liew FY (1995) Chemoattraction of human blood T lymphocytes by interleukin-15. J Exp Med 181:1255

    Google Scholar 

  159. McInnis IB, Al-Mughales J, Field M, Leung BP, Huang F-P, Dixon R, Sturrock RD, Wilkinson PC, Liew FY (1996) The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat Med 2:175

    Google Scholar 

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  1. Rheumatic Diseases Division of The Department of Internal Medicine, The University of Texas Southwestern Medical School, 5323 Harry Hines Blvd., 75235-8884, Dallas, TX, USA

    Nancy Oppenheimer-Marks & Peter E. Lipsky

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  1. Nancy Oppenheimer-Marks
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Oppenheimer-Marks, N., Lipsky, P.E. Adhesion molecules in rheumatoid arthritis. Springer Semin Immunopathol 20, 95–114 (1998). https://doi.org/10.1007/BF00832001

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