Abstract
o,p′-Dichlorodiphenyldichloroethane (o,p′-DDD) and Perthane, when added in a concentration of 312 μM to homogenate and cytoplasmic fraction of dog adrenals, activate glutathione reductase. In a concentration of 156 μM, o,p′-DDD and Perthane do not affect glutathione reductase activity of the dog adrenals. When given in vitro, o,p′-DDD and Perthane activate glutathione reductase of the guinea pig adrenals. o,p′-DDD has no effect on glutathione reductase activity of the cytoplasmic fraction of dog liver and kidney, thus confirming the high specificity of its effect on the adrenal cortex.
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Komissarenko, V.P., Chelnakova, I.S. & Mikosha, A.S. Effect of o,p-dichlorodiphenyldichloroethane and perthane in vitro on glutathione reductase activity in the adrenals of dogs and guinea pigs. Bull Exp Biol Med 85, 152–154 (1978). https://doi.org/10.1007/BF00800110
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DOI: https://doi.org/10.1007/BF00800110