Skip to main content
SpringerLink
Log in

Effect of noise stress and ethanol intake on hearts of spontaneously hypertensive rats

  • Original Contributions
  • Published:
Basic Research in Cardiology Aims and scope Submit manuscript

Summary

The pathogenesis and progression of hypertensive heart disease are unclear; however, both involve a genetic predisposition and environmental influences. To test the role of exogenous factors, we examined the hearts of spontaneously hypertensive rats (SHR) exposed to noise stress and ethanol intake. Twenty-two SHR and nine normotensive Wistar rats (NWR) were continuously exposed to a 65 db, 4 and 250 Hz tone for 52 weeks. Twelve of these SHR aged 20–22 weeks were concomitantly given 20% ethanol in their drinking water up to week 52. Eight SHR and 12 NWR served as controls. We examined hemodynamic parameters, the cardiac configuration, the cardiac microvasculature, interstitial tissue, and ischemic myocardial lesions. We found that noise stress significantly increased the microvessel wall area, the number of microvessels with an outer diameter >19 μm, the degree of cardiac fibrosis, and the extent of ischemic myocardial lesions in SHR, but not in NWR. These effects were all ameliorated and the diastolic blood pressure was lowered by the ingestion of ethanol. Cardiac weights and dimensions, heart rate and dp/dtmax were not influenced by either noise or ethanol intake. These results suggest that hypertensive heart disease in SHR can be aggravated by noise stress. Ethanol ameliorates these changes by mechanisms which remain to be explored.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Abdel-Rahman AA, Wooles WR (1987) Ethanol-induced hypertension involves impairment of baroreceptors. Hypertension 10:67–73

    Google Scholar 

  2. Blödner R, Kühne C, Mühlig P, Herrmann H-J (1989) Progress in application of the image analysing system quantimet 720 in the histomorphometry of the microcirculatory system. Gegenbaurs Morphol Jahrb 135:115–120

    Google Scholar 

  3. Brilla CG, Maisch B, Weber KT (1993) Renin angiotensin system and myocardial collagen matrix remodelling in hypertensive heart disease: in vivo and in vitro studies on collagen matrix regulation. Clin Investig 71:35–41

    Google Scholar 

  4. Butler AJ, Eagleton MJ, Wang D, Howell RL, Strauch AR, Khasgiwala V, Smith HC (1991) Induction of the proliferative phenotype in differentiated myogenic cells by hypoxia. J Biol Chem 266: 18250–18258

    Google Scholar 

  5. Chan TCK, Sutter MC (1983) Ethanol consumption and blood pressure. Life Sci 33:1965–1973

    Google Scholar 

  6. Chan TCK, Wall RA, Sutter MC (1985) Chronic ethanol consumption, stress, and hypertension. Hypertension 7:519–524

    Google Scholar 

  7. Factor SM, Bhan R, Minase T, Wolinsky H, Sonnenblick E (1981) Hypertensive-diabetic cardiomyopathy in the rat. An experimental model of human disease. Am J Pathol 102:219–228

    Google Scholar 

  8. Factor SM, Minase T, Cho S, Fein F, Capasso JM, Sonnenblick EH (1984) Coronary microvascular abnormalities in the hypertensive-diabetic rat. A primary cause of cardiomyopathy? Am J Pathol 116:9–20

    Google Scholar 

  9. Falange V, Julien JM (1990) Observations in the potential role of transforming-growth-factor-beta in cutaneous fibrosis systemic sclerosis. Ann N Y Acad Sci 593:161–171

    Google Scholar 

  10. Friberg P, Folkow B, Nordlander M (1985) Structural adaption of the rat left ventricle in response to pressure and volume loads. Acta Physiol Scand 125:67–79

    Google Scholar 

  11. Gibbons GH, Dzau V (1994) The emerging concept of vascular remodeling. N Engl J Med 330:1431–1438

    Google Scholar 

  12. Haller H, Behrend M, Park JK, Distler A, Luft FC (1994) Monocyte infiltration and c-fms expression in hearts of spontaneously hypertensive rats. Hypertension (in press)

  13. Hatton DC, Bukoski RD, Edgar S, McCarron DA (1992) Chronic alcohol consumption lowers blood-pressure but enhances vascular contractility in Wistar rats. J Hypertens 10:529–537

    Google Scholar 

  14. Herrmann H-J, Fiedler U, Blödner R, Reichert S, Meyer R (1993) Automated histomorphometry of interstitial reaction in the heart. J Pharmacol Toxicol Meth 30:133–136

    Google Scholar 

  15. Herrmann H-J, Moritz V, Kühne C (1992) Structural wall tissue alterations of the microvasculature in the course of spontaneous hypertension of rats. Int J Microcirc Clin Exp 11:1–20

    Google Scholar 

  16. Herrmann H-J, Mühlig P (1992) Causative role of coronary microvessels for the development and progression of chronic myocardial lesions in spontaneously hypertensive rats (SHR). Basic Res Cardiol 87:489–502

    Google Scholar 

  17. Herrmann H-J, Mühlig P, Blödner R, Kühne C (1992) Histomorphometry of focal myocardial lesions by means of the automatic image analysis. Exp Toxic Path 44:108–110

    Google Scholar 

  18. Howe PRC, Rogers PF, Morris MJ, Chalmers JP, Smith RM (1986) Plasma catecholamines and neuropeptide as indices of sympathetic nerve activity in normotensive and stroke-prone spontaneously hypertensive rats. J Cardiovasc Pharmacol 8:1113–1121

    Google Scholar 

  19. Howe PRC, Rogers PF, Smith RM (1989) Effects of chronic alcohol consumption and alcohol withdrawal on blood pressure in stroke-prone spontaneously hypertensive rats. J Hypertension 7:387–393

    Google Scholar 

  20. Jones JV, Raine AEG, Sanderson JE, Caretta R, Graham DI (1988) Adverse effect of chronic alcohol ingestion on cardiac performance in spontaneously hypertensive rats. J Hypertension 6:419–422

    Google Scholar 

  21. Kolin A, Brezina A, Lewis AJ, Norris JW (1989) Quantitative evaluation of myocardial injury induced by acute cerebral ischaema and its prevention by beta-adrenergic blockade. An structural morphometry study. Br J Exp Path 70:659–667

    Google Scholar 

  22. Korner PI, Bobik A, Oddie C, Friberg P (1992) Sympatho-adrenal-system and development of cardiac and vascular amplifier properties in SHR. Colloque Inserm 218:237–239

    Google Scholar 

  23. Mai M, Geiger H, Hilgers KF, Veelken R, Mann JFE, Dämmrich J, Luft FC (1993) Early interstitial changes in hypertension-induced renal injury. Hypertension 22:754–765

    Google Scholar 

  24. Marcus ML, Chilian WM, Kanatsuka H, Dellsperger KC, Eastham CL, Lamping KG (1990) Understanding of the coronary circulation through studies at the microvascular level. Circulation 82:1–7

    Google Scholar 

  25. Morvai V, Ungvary G, Varga K, Albert K, Folly G (1979) Effect of longterm alcohol intake on the cardiovascular system of the rat. Acta physiol Acad Sci Hung 54:369–379

    Google Scholar 

  26. Ogawa S, Shreeniwas R, Butura C, Brett C, Stern DM (1990) Modulation of endothelial function by hypoxia: perturbation of barrier and anticoagulant function and induction of a novel factor × activator. Adv Exp Med Biol 281:303–312

    Google Scholar 

  27. Ogawa H, Tanaka T, Sasagawa S, Akai S, Akai T, Takahashi M, Yamaguchi M (1992) Enhanced emotional responses with aging in strokeprone spontaneously hypertensive rats (SHRSP). Colloque Inserm 218:169–171

    Google Scholar 

  28. Punkt K, Erzen J, Krug H, Punkt J, Seidler E (1989) Histomorphometry — the method of choice in quantifying dehydrogenase histochemistry. Acta Histochem 87:63–69

    Google Scholar 

  29. Rosen P, Boulton M, Moriarty P, Khaliqu A, McLeod D (1991) Effect of varying oxygen concentrations on the proliferation of retinal microvascular cells in vitro. Exp Eye Res 53:597–601

    Google Scholar 

  30. Sanderson JE, Jones JV, Graham DI (1983) Effect of chronic alcohol ingestion on the heart and blood pressure in spontaneously hypertensive rats. Clin Exp Hypertension (A) 5:673–689

    Google Scholar 

  31. Van der Laarse WJ, Diegenbach PC, Elzinga G (1989) Maximum rate of oxygen consumption and quantitative histochemistry of succinate dehydrogenase in single muscle fibres of Xenopus laevis. J Muscle Res Cell Motil 10:221–228

    Google Scholar 

  32. Veelken R, Sawin LL, DiBona GF (1990) Epicardial 5-HT3 receptors in circulatory control in conscious Sprague-Dawley rats. Am J Physiol 258:H466-H472

    Google Scholar 

  33. Wachstein M, Meisel E (1957) Histochemistry of hepatic phosphatase at a physiologic pH (with special reference to the demonstration of bile canaliculi). Am J Clin Pathol 27:13–23

    Google Scholar 

  34. Weber KT, Brilla CG (1992) Factors associated with reactive and reparative fibrosis of the myocardium. Basic Res Cardiol 87:291–301

    Google Scholar 

Download references

Author information

Author notes

  1. F. C. Luft

    Present address: Max Delbrück Center for Molecular Medicine, Rudolph Virchow University Hospital, Free University of Berlin, Berlin, Germany

Authors and Affiliations

  1. Max Delbrück Center for Molecular Medicine, Rudolph Virchow University Hospital, Free University of Berlin, Berlin, Germany

    H. -J. Herrmann, H. G. E. Rohde, W. Schulze & C. Eichhorn

  2. The Franz Volhard Clinic, Rudolph Virchow University Hospital, Free University of Berlin, Berlin, Germany

    H. -J. Herrmann, H. G. E. Rohde, W. Schulze & C. Eichhorn

Authors
  1. H. -J. Herrmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. G. E. Rohde
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. Schulze
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Eichhorn
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. C. Luft
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Herrmann, H.J., Rohde, H.G.E., Schulze, W. et al. Effect of noise stress and ethanol intake on hearts of spontaneously hypertensive rats. Basic Res Cardiol 89, 510–523 (1994). https://doi.org/10.1007/BF00794951

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00794951

Key words

Search

Navigation