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Synthesis of derivatives of pyrazino[1,2-a]benzimidazole, aza analogs ofβ-carboline

  • Chemistry
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Conclusions

  1. 1.

    A new method of synthesis of derivatives of imidazo[1,2-a]pyrazine and pyrazino[1,2-a]benzimidazole, representatives of new heterocyclic systems, was proposed.

  2. 2.

    It was shown that dehydrogenation over Raney nickel under mild conditions is a convenient method of synthesis of benzimidazoles from benzylimidazolines and of benzimidazo[1,2-a]quinoxaline derivatives from the corresponding tetrahydro derivatives.

  3. 3.

    A method of synthesis was developed for 2-benzoylbenzimidazoles by oxidation of the widely accessible 2-benzylbenzimldazoles.

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Chemicopharmaceutical Institute, Moscow

    V. I. Shvedov, L. B. Altukhova, L. A. Chernyshkova & A. N. Grinev

Authors
  1. V. I. Shvedov
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  2. L. B. Altukhova
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  3. L. A. Chernyshkova
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  4. A. N. Grinev
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 10, pp. 15–20, October, 1969.

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Shvedov, V.I., Altukhova, L.B., Chernyshkova, L.A. et al. Synthesis of derivatives of pyrazino[1,2-a]benzimidazole, aza analogs ofβ-carboline. Pharm Chem J 3, 566–570 (1969). https://doi.org/10.1007/BF00762071

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  • DOI: https://doi.org/10.1007/BF00762071

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