Summary
In a fatal case of neuroleptic malignant syndrome, a muscle sample taken within 1h of death showed acute myopathic features with absence of muscle glycogen and neutral lipid. These features suggest that hyperpyrexia in this syndrome may be caused by heat production from uncoupled phosphorylation in muscle and imply that the primary biochemical abnormality responsible for this uncontrolled heat production might be muscular rather than hypothalamic.
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References
Burke RE, Fahn S, Mayeux R, Weinberg H, Louis K, Willner JH (1981) Neuroleptic malignant syndrome caused by dopamine depleting drugs in a patient with Huntington's disease. Neurology 31:1022–1026
Caroff SN, Rosenberg H, Gerber JC (1983) Neuroleptic malignant syndrome and malignant hyperthermia. Lancet I:244
Editorial (1984) Neuroleptic malignant syndrome. Lancet I:544–546
Follefson G (1982) A case of neuroleptic malignant syndrome; in vitro muscle comparison with malignant hyperthermia. J Clin Psychopharmacol 2:266–270
Gibb WRG, Wedzicha JA, Hoffbrand BI (1986) Recurrent neuroleptic malignant syndrome and hyponatraemia. J Neurol Neurosurg Psychiatry 49:960–961
Goulon M, Rohan-Chabot P, Gajdos P, Bismuth C, Conso F (1983) Beneficial effects of dantrolene in the treatment of neuroleptic malignant syndrome; report of 2 cases. Neurology 33:516–518
Granato JE, Stern BJ, Ringel SH, Karin A, Krumholz A, Coyle J, Adler S (1983) Neuroleptic malignant syndrome; successful treatment with dantrolene and bromocryptine. Ann Neurol 14:89–90
Guze BH, Baxter LR (1986) Neuroleptic malignant syndrome. N Engl J Med 313:163–166
Itoh H, Ohtsuka N, Ogita K, Yagi G, Miura S, Koga Y (1977) Malignant neuroleptic syndrome; its present status in Japan and clinical problems. Folia Psychiatr Neurol (Jpn) 31:565–576
Lotstra F, Linkowski P, Mendlewicz J (1983) General anaesthesia after neuroleptic malignant syndrome. Biol Psychiatry 18:243–247
Morris H, McCormick WF, Reinarz JA (1980) Neuroleptic malignant syndrome. Arch Neurol 37:462–463
Sechi GP, Tanda F, Mutani R (1984) Fatal hyperpyrexia after withdrawal of levodopa. Neurology 34:249–251
Smego RA, Durack DT (1982) The neuroleptic malignant syndrome. Arch Intern Med 142:1183–1185
Toru M, Matsuda O, Makiguchi K, Sugano K (1981) Neuroleptic malignant syndrome-like state following withdrawal of anti-parkinsonian drugs. J Nerv Ment Dis 169:324–327
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Martin, D.T., Swash, M. Muscle pathology in the neuroleptic malignant syndrome. J Neurol 235, 120–121 (1987). https://doi.org/10.1007/BF00718024
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DOI: https://doi.org/10.1007/BF00718024