Summary
Brains from 75 people were studied to assess the occurrence of senile plaques and argyrophilic tangles in a population selected as far as possible for its probable mental normality.
Histological methods were devised and validated to permit quantitative assessment of the numbers of these lesions as well as their frequency of occurrence in the two areas studied—frontal cortex and Ammon's horn.
There was significant correlation between increasing age over 60 years and the proportion of patients who showed these changes at both sites. No definite relationship was found between age, site of occurrence and the intensity of the pathological changes.
Zusammenfassung
75 menschliche Gehirne wurden untersucht, um das Auftreten von senilen Plaques und argyrophilen Fibrillen in einer wegen mutmaßlicher psychischer Unauffälligkeit ausgewählten Population zu erfassen. Die histologischen Methoden wurden standardisiert und überprüft, um eine quantitative Erfassung der Zahl und Häufigkeit dieser Läsionen in zwei untersuchten Hirnregionen — Frontalrinde und Ammonshorn — zu ermöglichen. Es fand sich eine signifikante Korrelation zwischen zunehmendem Alter über 60 Jahren und dem Anteil an Patienten mit diesen Veränderungens in beiden Regionen. Zwischen Alter, Ort des Auftretens und Intensität der pathologischen Veränderungen fand sich keine Beziehung.
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Dayan, A.D. Quantitative histological studies on the aged human brain. Acta Neuropathol 16, 85–94 (1970). https://doi.org/10.1007/BF00687663
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DOI: https://doi.org/10.1007/BF00687663