Abstract
Molecular descriptors such as quantum chemical indices, substituent constants, substituent chemical shifts values of monosubstituted benzenes, and different data analyses (linear regression, dual substituent parameters, and multivariate analysis) have been comparatively used in order to rationalize the electronic substituent effects and to predict13C nuclearmagnetic resonance (NMR) and vibrational spectroscopy (IR) data of the 14 title compounds. The results have been compared with those previously obtained for the biologically active 4′-substituted 4-aminodiphenylsulfones, inhibitors of the dihydropteroate synthase enzyme. Both the 4-nitro and the 4-amino sulfone series show similar transmission of the electronic substituent effects through the C(1)-SO2-C(1′) moiety by a hyperconjugative mechanism. Good predictions of the spectroscopic data are obtained with the different models considered. However, the partial least-squares method and principal componenent analysis seem to be the most powerful predictive tools.
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Craik, D. J.Annu. Rep. N.M.R. Spectrosc.,1983,15, 1.
Topsom, R. D.Prog. Phys. Org. Chem.,1987,16, 193.
Shorter, J. InThe Chemistry of Sulphones and Sulphoxides; Patai, S.; Rappoport, Z.; Stirling, C., Eds.; John Wiley & Sons: Chichester, England,1988, pp. 483–540; Hargittai, I. Ibid., pp. 33–53.
Chandrasekaran, R., Perumal, S., Wilson, D. A.Magn. Reson. Chem.,1987,25, 1001.
Lynch, M. B.Can. J. Chem.,1977,55, 541.
Taft, R. W., Topsom, R. D.Prog. Phys. Org. Chem.,1987,16, 1.
Topsom, R. D.Prog. Phys. Org. Chem.,1987,16, 125.
Edlund, U., Wold, S.J. Magn. Reson.,1980,37, 183.
De Benedetti, P. G., Folli, U.; Iarossi, D.; Frassineti, C.J. Chem. Soc., Perkin Trans. II,1985, 1527.
Wold, S.Technometrics,1978,20, 397.
Dunn III, W. J.; Wold, S.; Edlund, U.; Hellberg, S.; Gasteiger, J.Quant. Struct.-Act. Relat.,1984,3, 131.
Ewing, D. F.Org. Magn. Reson.,1979,12, 499.
Szmant, H. H. InSulfur in Organic and Inorganic Chemistry; Senning, A., Ed.; Dekker: New York,1971; Vol. 1, pp. 107–152.
Buchanan, G. W.; Reyes-Zamora, C.; Clarke, D. E.Can. J. Chem.,1974,52, 3895.
Chang, C.; Floss, H. G.; Peck, G. E.J. Med. Chem.,1975,18, 505.
Nelson, G. L.; Williams, E. A.Prog. Phys. Org. Chem.,1976,12, 107.
Reynolds, W. F., Gomes, A., Maron, A., MacIntyre, D. W., Tanin, A., Hamer, G. K., Peat, I. R.Can. J. Chem.,1983,61, 2376.
Dawson, D. A.; Reynolds, W. F.Can. J. Chem.,1975,53, 373.
Hehre, W. J.; Taft, R. W.; Topsom, R. D.Prog. Phys. Org. Chem.,1976,12, 164.
Robinson, C. N.; Slater, C. D.; Covington III, J. S.; Chang, C. R.; Dewey, L. S.; Franceschini, J. M.; Fritzsche, J. L.; Hamilton, J. E.; Irving C. C., Jr.; Morris, J. M.; Norris, D. W.; Rodman, L. E.; Smith, V. I.; Stablein, G. E.; Ward, F. C.J. Magn. Reson.,1980,41, 293.
Swain, C. G.; Lupton, E. C.J. Am. Chem. Soc.,1968,90, 4328.
Furukawa, N.; Fujihara, H. InThe Chemistry of Sulphones and Sulphoxides; Patai, S.; Rappoport, Z.; Stirling, C., Eds.; John Wiley & Sons: Chichester, England;1988, pp. 541–581.
Johnels, D.; Edlund, U.; Grahn, H.; Hellberg, S.; Sjostrom, M.; Wold, S.; Clementi, S.; Dunn III, W. J.J. Chem. Soc., Perkin Trans. II,1983, 863.
Alunni, S.; Clementi, S.; Edlund, U.; Johnels, D.; Hellberg, S.; Sjostrom, M.; Wold, S.Acta Chem. Scand., Ser. B,1983,37, 47.
Dunn III, W. J.; Lins, C.; Kumar, G.; Manimaran, T.;Grigoras, S.; Edlund, U.; Wold, S.Org. Magn. Reson.,1983,21, 450.
Johnels, D.; Edlund, U.; and Wold, S.J. Chem. Soc., Perkin Trans. II,1985, 1339.
Johnels, D.; Edlund, U.; Johansson, E.; Wold, S.J. Magn. Reson.,1983,55, 316.
Lipkowitz, K. B.J. Am. Chem. Soc.,1982,104, 2647.
Hiberty, P. C.; Ohanessian, G.J. Am. Chem. Soc.,1984,106, 6963.
Politzer, P.; Lane, P.; Jayasuriya, K.; Domelsmith, N. L.J. Am. Chem. Soc.,1987,109, 1899.
Hargittai, I. InOrganic Sulfur Chemistry; Bernardi, F.; Csizmadia, I. G.; Mangini, A., Eds.; Elsevier: Amsterdam; 1985, pp. 69–132.
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Cocchi, M., Iarossi, D., Menziani, M.C. et al. Correlation and multivariate analyses of the spectroscopic data in 4′-substituted 4-nitrodiphenylsulfones. Struct Chem 2, 47–55 (1991). https://doi.org/10.1007/BF00673489
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DOI: https://doi.org/10.1007/BF00673489