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Reduction of 20-oxosteroids to 20α-alcohols by means ofActinomyces roseochromogenus

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Chemistry of Natural Compounds Aims and scope

Conclusions

A culture ofActinomyces roseochromogenus ATCC 3347 and the corresponding cell-free preparation reduce 17α-oxygen-containing 20-oxopregnanes to the 20α-alcohol. A culture ofA. roseochromogenus ATCC 3347 is capable of reducing Δ4-3-oxo- to 3β-hydroxy-5α-steroids, as has been shown by fermentation with 16α, 17-epoxyprogesterone as an example. It has been shown that certain substituents in the steroid molecule affect the course of the 20α-reduction by a culture ofA. roseochromogenus ATCC 3347.

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Authors and Affiliations

  1. Institute of the Chemistry of Natural Compounds, AS USSR, USSR

    Leonid M. Kogan, E. A. Elin, V. I. Mel'nikova & I. V. Torgov

Authors
  1. Leonid M. Kogan
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  2. E. A. Elin
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  3. V. I. Mel'nikova
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  4. I. V. Torgov
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Additional information

Khimiya Prirodnykh Soedinenii, Vol. 5, No. 3, pp. 149–156, 1969

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Kogan, L.M., Elin, E.A., Mel'nikova, V.I. et al. Reduction of 20-oxosteroids to 20α-alcohols by means ofActinomyces roseochromogenus . Chem Nat Compd 5, 128–132 (1969). https://doi.org/10.1007/BF00636003

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