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Immunotheapy and immunodiagnostic studies in carcinoma of the bladder

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Summary

Non-specific immunotherapy of superficial bladder cancer using Bacillus Calmette-Guérin (BCG) represents a successful application of immunotherapy against a human cancer. Clinical studies in the late 1970's first demonstrated the efficacy of this form of therapy against papillary forms of transitional cell carcinoma. Subsequent studies confirmed the value of BCG in extending the time to recurrence and decreasing both the rate of recurrence and the rate of progression of recurrent tumor to higher stages. These studies also showed BCG to be effective against carcinoma in situ. However, the mechanism of action of BCG has not yet been defined, nor has the optimal dosage schedule and route of administration been determined. Preliminary laboratory studies of tumor-specific therapy with tumor-derived protein extracts are encouraging, and suggest that this form of immunotherapy may be almost as efficacious as BCG therapy. Clinical trials of intravesical alpha-2 interferon for carcinoma in-situ are also in progress.

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Authors and Affiliations

  1. Division of Urology, Department of Surgery, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78284, San Antonio, Texas, USA

    Michael F. Sarosdy, Steven H. Pickett, Brian J. Stogdill, Marianne G. Rochester, Rex H. Reynolds, Howard M. Radwin & Donald L. Lamm

  2. Department of Urology, West Virginia University, Morgantown, West Virginia, USA

    Michael F. Sarosdy, Steven H. Pickett, Brian J. Stogdill, Marianne G. Rochester, Rex H. Reynolds, Howard M. Radwin & Donald L. Lamm

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  1. Michael F. Sarosdy
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  2. Steven H. Pickett
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  3. Brian J. Stogdill
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  4. Marianne G. Rochester
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  5. Rex H. Reynolds
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  6. Howard M. Radwin
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  7. Donald L. Lamm
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Sarosdy, M.F., Pickett, S.H., Stogdill, B.J. et al. Immunotheapy and immunodiagnostic studies in carcinoma of the bladder. World J Urol 3, 215–217 (1986). https://doi.org/10.1007/BF00632181

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