Summary
Buprenorphine, (Temgesic), a N-cyclopropylmethyl derivative of oripavine, is both an agonist and antagonist of morphine. Its effect on the motility of the sphinceter of Oddi (SO) in humans have been investigated by endoscopic manometry (EM).
Buprenorphine leads to a significant decrease in the amplitude of SO contraction waves without altering other parameters. Thus, it has no morphine-like effect on SO motility, but it does act like a partial antagonist of morphine in reducing the amplitude of SO contraction waves.
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Cuer, J.C., Dapoigny, M., Ajmi, S. et al. Effects of buprenorphine on motor activity of the sphincter of Oddi in man. Eur J Clin Pharmacol 36, 203–204 (1989). https://doi.org/10.1007/BF00609196
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DOI: https://doi.org/10.1007/BF00609196