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Secretion of the gastrokinetic agent cisapride in human milk

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Summary

Ten puerperal women were treated with the gastrokinetic agent Cisapride 20 mg 8-h by oral tablets. Breast milk levels of Cisapride had reached a steady state by treatment day 3. Day 4 breast milk levels were 6.2±1.3 and serum levels 137±8.1 ng/ml (mean±SEM). The breastfeeding infant of a woman on the above treatment would ingest an amount of Cisapride 600–800 times lower than the usual therapeutic dose.

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References

  • Ahlenius S, Brown R, Engel J, Lundborg P (1972) Learning deficits in 4 weeks old offspring of the nursing mothers treated with the neuroleptic drug penfluridol. Naunyn-Schmiedebergs Arch Pharmacol 279: 31–37

    Google Scholar 

  • Brouwers JRBJ, Assies J, Wiersinga WM, Huizing G, Tytgat GN (1980) Plasma prolactin levels after acute and subchronic oral administration of domperidone and of metoclopramide: A cross-over study in healthy volunteers. Clin Endocrinol 12: 435–440

    Google Scholar 

  • Giacoia GP, Catz CS (1979) Drugs and pollutants in breast milk. Clin Perinatol 6: 181–196

    Google Scholar 

  • Hofmeyr GJ, van Iddekinge B (1983) Domperidone and lactation. Lancet 1: 647

    Google Scholar 

  • Hofmeyr GJ, van Iddekinge B, Blott JA (1985) Domperidone secretion in breast milk and effect on puerperal prolactin levels. Br J Obstet Gynaecol 92: 141–144

    Google Scholar 

  • Lewis PJ, Devenish C, Kahn C (1980) Controlled trial of metoclopramide in the initiation of breast feeding. Br J Clin Pharmacol 9: 217–219

    Google Scholar 

  • Reyntjens A (1983) 51619 and prolactin release. Janssen Research Products information service N30700

  • Wilson JT (1981) Drugs and breast feeding. Semin Perinatol 3: 271–278

    Google Scholar 

  • Woestenborghs R, Lorreyne W, Embrechts L, Heykants J (1983) High-performance liquid chromatographic determination of R51619 in plasma samples. Janssen preclinical research report R51619/19

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa

    G. J. Hofmeyr & E. W. W. Sonnendecker

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  1. G. J. Hofmeyr
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  2. E. W. W. Sonnendecker
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Hofmeyr, G.J., Sonnendecker, E.W.W. Secretion of the gastrokinetic agent cisapride in human milk. Eur J Clin Pharmacol 30, 735–736 (1986). https://doi.org/10.1007/BF00608226

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  • DOI: https://doi.org/10.1007/BF00608226

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