Summary
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1.
The effects of reserpine and harman derivatives on the sodium transport across the frog bladder were examined using a short-circuit current method. The effects of harman derivatives on the Na,K-ATPase activity of the frog kidney were also investigated.
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2.
Reserpine and harman derivatives inhibited active sodium transport of the frog bladder and their inhibitory effect decreased as reserpine>harmine >harmaline=harman>harmalol.
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3.
Harman derivatives inhibited Na,K-ATPase activity of the frog kidney.
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4.
These results suggest that reserpine and harman derivatives inhibit active sodium transport by suppressing the Na,K-ATPase activity of the frog bladder.
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Marumo, F., Mishina, T., Asano, Y. et al. The inhibitory effect of reserpine on the active sodium transport across the frog bladder. Pflugers Arch. 365, 15–19 (1976). https://doi.org/10.1007/BF00583623
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DOI: https://doi.org/10.1007/BF00583623