Abstract
The aim of the present study was to compare the cutaneous postischaemic hyperaemic response in young insulin-dependent diabetic patients and healthy subjects during normoglycaemia, acute insulin-induced hypoglycaemia and in the posthypoglycaemic state. After a night of normoglycaemia the cutaneous postischaemic hyperaemic response in the forearm skin, measured by the transcutaneousPO 2 method, was the same in both groups. A reduction of the maximal postischaemic vasodilatory response was observed in diabetic patients from 2.4±0.3 to 2.0±0.2 kPa (P<0.05) and in control subjects from 2.7±0.3 to 1.8±0.2 kPa (P<0.02) during insulin-induced hypoglycaemia (plasma glucose<2 mmol/l). Complete recovery of the vasodilatory response occurred in subjects in the posthypoglycaemic state. We conclude that hypoglycaemia induced a transient reduction of the vasodilatory response, which was rapidly reversed after glucose counter-regulation, in both diabetic patients and healthy controls. Thus, the prevailing blood glucose concentration must be taken into account when the postischaemic vasodilatory response is investigated in diabetic patients.
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Åman, J., Berne, C., Ewald, U. et al. Impaired cutaneous reactive hyperaemia during hypoglycaemia in young insulin-dependent diabetic patients and healthy controls. Acta Diabetol 29, 25–28 (1992). https://doi.org/10.1007/BF00572825
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DOI: https://doi.org/10.1007/BF00572825