Skip to main content
SpringerLink
Log in

Elevated serum parathyroid hormone concentration during treatment with high ceiling diuretics

  • Short Communications
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

Serum concentrations of parathyroid hormone (s-PTH) calcium, phosphorus and alkaline phosphatase were measured during treatment with furosemide or bumetanide for congestive heart failure. Significant elevations both of s-PTH and alkaline phosphatase were found, whereas serum calcium concentration was descreased. The changes were not related to the dose of drug or to the duration of treatment. It is concluded that treatment with furosemide or bumetanide may cause hypocalcaemia, resulting in elevation of s-PTH. The increased concentration of alkaline phosphatase may indicate accelerated bone remodelling, as found in primary hyperparathyroidism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Christensen MS (1976) A sensitive radioimmunoassay of parathyroid hormone in human serum using a specific extraction procedure. Scand J Clin Lab Invest 36: 313–322

    Google Scholar 

  • Christensen MS (1979) Radioimmunoassay of human parathyroid hormone: Review with special reference to hyperparathyroidism in renal disease. Dan Med Bull 26: 157–175

    Google Scholar 

  • Christiansen C, Naestoft J, Hvidberg EF, Larsen N-E, Petersen B (1975) An easy procedure for in vivo estimation of protein binding and correlation of elevated serum values induced by venous stasis. Clin Chim Acta 62: 65–71

    Google Scholar 

  • Coe FL, Canterbury JM, Firpo JJ, Reiss E (1973) Evidence for secondary hyperparathyroidism in idiopathic hypercalciuria. J Clin Invest 52: 134–142

    Google Scholar 

  • Fuss M, Backer M De, Braumann J, Nijs-Dewolf N, Manderlier T, Braumann H, Corvilain J (1976) Parathyroid hormone plasma level in untreated chronic renal failure and in hemodialysed patients. Nephron 17: 144–154

    Google Scholar 

  • Martinez-Maldonado M, Eknoyan G, Suki WN (1973) Diuretics in nonedematous states. Arch Intern Med 131: 797–808

    Google Scholar 

  • Suki WN, Yium JJ, Von Minden M, Saller-Hebert C, Eknoyan G, Martinez-Maldonado M (1970) Acute treatment of hypercalcemia with furosemide. N Engl J Med 283: 836–840

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Medicine C, Clinical Chemistry and Clinical Physiology, Glostrup Hospital, Glostrup, Denmark

    J. Elmgreen, L. Tougaard, A. Leth & M. S. Christensen

Authors
  1. J. Elmgreen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. Tougaard
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Leth
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. S. Christensen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Elmgreen, J., Tougaard, L., Leth, A. et al. Elevated serum parathyroid hormone concentration during treatment with high ceiling diuretics. Eur J Clin Pharmacol 18, 363–364 (1980). https://doi.org/10.1007/BF00561397

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00561397

Key words

Search

Navigation