Summary
This study examines the role of a neostigmine-induced increase in acetylcholine on the aldosterone stimulating effect of metoclopramide.
Six normal male volunteers received the following three treatments in a cross-over randomized sequence: neostigmine, 0.5 mg s.c.; metoclopramide 10 mg i.v.; and neostigmine 0.5 mg s.c., followed by metoclopramide 10 mg i.v.
Metoclopramide increased serum aldosterone significantly to 161% of basal level at 15 min. With neostigmine aldosterone levels peaked (129%) significantly at 30 min. In the presence of neostigmine, however, the metoclopramide-induced aldosterone response was blunted significantly.
These results would suggest that presynaptic autoreceptors depresses the continued output of acetylcholine, thereby blunting the aldosterone responses to metoclopramide significantly.
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De Sommers, K., Meyer, E.C. & van Wyk, M. Effect of neostigmine on metoclopramide-induced aldosterone secretion in man. Eur J Clin Pharmacol 36, 411–413 (1989). https://doi.org/10.1007/BF00558305
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DOI: https://doi.org/10.1007/BF00558305