Summary
Decreased elimination of a combined formulation of Sotalol (160 mg) and hydrochlorothiazide (25 mg) was found in patients with moderate renal insufficiency. Very slight accumulation of sotalol and hydrochlorothiazide was observed, so it appears unnecessary to reduce the dosage in patients with a creatinine clearance of 30 ml/min or more.
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References
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Kher, A., Fillastre, J.P., Fourtillan, J.B. et al. Pharmacokinetics of a fixed combination of sotalol and hydrochlorothiazide in hypertensive patients with moderate renal insufficiency. Eur J Clin Pharmacol 27, 361–362 (1984). https://doi.org/10.1007/BF00542176
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DOI: https://doi.org/10.1007/BF00542176