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The effect of physostigmine and neostigmine on the concentration of glycogen in the liver of the rat

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Summary

The intravenous injection of physostigmine was found to produce a decrease in the concentration of glycogen in liver and an increase in the concentration of glycogen in heart auricles of the rat. Neostigmine did not produce the glycogenolysis in liver. The glycogenolytic effect of physostigmine was accompanied by an increase in blood glucose level.

Propranolol, mebutamate, atropine and pretreatment by reserpine and guanethidine were found to block the glycogenolytic effect of physostigmine. In vitro physostigmine did not produce the glycogenolysis in liver, whereas adrenaline produced such an effect. Hexamethonium, in doses used in these experiments, did not block this type of physostigmine action.

The glycogenolytic effect of physostigmine was also present in the adrenalectomized animals. The results of these experiments indicate that the glycogenolytic effect of physostigmine was most probably due to a general sympathetic activation produced by this substance. It seems therefore that this effect of physostigmine has a similar origin as the blood pressure rise produced by physostigmine in the rat, an effect which has also been attributed to a general sympathetic activation.

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Authors and Affiliations

  1. Department of Pharmacology, Department of Biochemistry Medical Faculty, Belgrade, Yugoslavia

    V. M. Varagić, M. Terzić & B. B. Mršulja

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  1. V. M. Varagić
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  2. M. Terzić
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  3. B. B. Mršulja
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Varagić, V.M., Terzić, M. & Mršulja, B.B. The effect of physostigmine and neostigmine on the concentration of glycogen in the liver of the rat. Naunyn-Schmiedebergs Arch. Pharmak. u. Exp. Path. 258, 229–237 (1967). https://doi.org/10.1007/BF00538527

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  • DOI: https://doi.org/10.1007/BF00538527

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