Abstract
A new route for the synthesis of 2-acyl-1,2,3,6,7,11b-hexahydropyrazino[2,1-a]isoquinolin-4-ones has been studied which includes a stage in which substituted piperazinones are obtained by reductive cyclization of N-cyanomethyl derivatives of 2-phenylethylamides of acylglycines under influence of Raney alloy in formic acid.
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Yu. S. Tsizin, O. V. Shekhter, N. L. Sergovskaya, and A. M. Bronshtein, Khim.farm. Zhur., No.9, 60 (1990).
C. S. Kim, N. J. Lee, and J. H. Kim. West German Pat. 3 324 532. Chem. Abs., 100, 209 869 (1984).
J. Sombroek. West German Pat., 3 316 928, Chem. Abs., 102, 113 530 (1985).
G. S. Sidhu, G. Thyagaryan, and M. Mazharuddin. Indian J. Chem., 2, No.4, 170 (1964).
T. Nakao, T. Goto, A. Kikami, Y. Naoi, K. Fujii, and K. Yoshida, Japan Pat., 8 007 252, Chem. Abs., 93, 113 976 (1980).
T. van Es and B Staskun, J. Chem. Soc., 5775 (1965).
N. L. Sergovskaya, S. A. Chernyak, O. V. Shekhter, and Yu. S. Tsizin, Khim. Geterotsikl. Soedin., No.8, 1107 (1992).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 197–201, February, 1993.
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Shekhter, O.V., Kuklenkova, O.B., Sergovskaya, N.L. et al. A new synthesis 2-acyl-1,2,3,6,7,11b-hexahydropyrazino[2,1-a]isoquinolin-4-ones based on N-cyanomethyl derivatives of 2-phenyl-ethylamides of acylglycines. Chem Heterocycl Compd 29, 170–173 (1993). https://doi.org/10.1007/BF00531659
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DOI: https://doi.org/10.1007/BF00531659