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Synthesis and dynamic stereochemistry of 1,5-disubstituted 2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-ones

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The 1-isopropyl and 1-benzyl derivatives of 1,5-tetrahydrobenzodiazepin-2-one were synthesized by alkylation under the conditions of phase-transfer catalysis. The inversion of the heterocycle was studied by PMR spectroscopy, and the free energies of activation were determined.

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Authors and Affiliations

  1. Institute of Biochemistry, Academy of Sciences of the Lithuanian SSR, 232021, Vil'nyus

    B. A. Puodzhyunaite, R. A. Yanchene, Z. A. Stumbryavichyute & P. P. Mikul'skis

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  1. B. A. Puodzhyunaite
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  2. R. A. Yanchene
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  3. Z. A. Stumbryavichyute
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  4. P. P. Mikul'skis
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 254–258, February, 1986.

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Puodzhyunaite, B.A., Yanchene, R.A., Stumbryavichyute, Z.A. et al. Synthesis and dynamic stereochemistry of 1,5-disubstituted 2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-ones. Chem Heterocycl Compd 22, 206–210 (1986). https://doi.org/10.1007/BF00519945

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  • DOI: https://doi.org/10.1007/BF00519945

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