Abstract
Recyclization of the pyrimidine ring with inclusion of the reagent in the newly formed ring to give indole derivatives of 2,3-disubstituted pyridines occurs in the reaction of the anhydro base of 4-(3-indolyl)pyrimidine with CH acids in the presence of triethylamine. The products react with formamide to give the pyrido[2,3-d]pyrimidine heterocyclic system.
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Translated from Khimiya Geterotsiklicheskikh Soedenii, No. 1, pp. 115–118, January, 1983.
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Stupnikova, T.V., Nuzhnaya, T.V., Klyuev, N.A. et al. Synthesis of indole derivatives of pyrido[2,3-d]pyrimidine. Chem Heterocycl Compd 19, 103–106 (1983). https://doi.org/10.1007/BF00512827
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DOI: https://doi.org/10.1007/BF00512827