Summary
A single injection of haloperidol (0.08 mg/kg) produced marked increases in HVA in rabbit brain. Of the dopamine-containing areas studied, the elevation of HVA was significantly greater in the frontal cortex than in the striatum, the tuberculum olfactorium or the parietal cortex. After chronic treatment, a tolerance phenomenon to the effects of haloperidol on HVA was observed only in the striatal and limbic areas. The present results suggest that the frontal cortex may be a preferential target for the antipsychotic activity of neuroleptic agents.
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Laduron, P., De Bie, K. & Leysen, J. Specific effect of haloperidol on dopamine turnover in the frontal cortex. Naunyn-Schmiedeberg's Arch. Pharmacol. 296, 183–185 (1977). https://doi.org/10.1007/BF00508472
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DOI: https://doi.org/10.1007/BF00508472